Istradefylline
Sponsors
University Of Turku, Kyowa Kirin, Inc., University of Chicago, Kyowa Kirin Co., Ltd., Randy Trumbower, PT, PhD
Conditions
Drug AbuseHepatic ImpairmentMyelopathyParkinson's DiseaseProgressive multiple sclerosisSpinal Cord Injuries
Phase 1
Effect of Mild Hepatic Impairment on the Pharmacokinetics of Istradefylline
CompletedNCT02256033
Start: 2014-08-31End: 2014-12-31Updated: 2024-04-25
A Study to Evaluate Abuse Potential of Istradefylline
CompletedNCT02609477
Start: 2016-01-31End: 2016-07-31Updated: 2024-04-25
Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury
Not yet recruitingNCT05217498
Start: 2027-09-01End: 2028-06-30Target: 40Updated: 2026-03-20
Phase 2
A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
CompletedNCT00455507
Start: 2007-03-31End: 2008-08-31Updated: 2012-08-29
A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy
CompletedNCT00955045
Start: 2002-08-31End: 2003-10-31Updated: 2024-04-25
Prospective, randomized, double-blind, placebo-controlled, single-center comparative trial evaluating oral Istradefylline 40 mg once daily for reducing microglial activation in the brain of patients with progressive multiple sclerosis (MS)
RecruitingCTIS2024-517336-21-00
Start: 2025-03-31Target: 34Updated: 2025-02-12
Phase 3
An Extension of Istradefylline in North American Parkinson's Disease Patients Who Have Completed Study 6002-INT-001
TerminatedNCT00199381
Start: 2005-10-31End: 2008-10-31Updated: 2024-05-17
Study of KW-6002 (Istradefylline) in Parkinson's Disease in Patients With Motor Response Complications on Levodopa
CompletedNCT00203957
Start: 2005-03-31End: 2007-02-28Updated: 2013-06-11
Study of KW-6002 (Istradefylline) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
CompletedNCT00955526
Start: 2009-07-31End: 2011-02-28Updated: 2012-08-29
Long-Term Safety Study of KW-6002 (Istradefylline) in Parkinson's Disease Patients
CompletedNCT00957203
Start: 2009-10-31End: 2012-03-31Updated: 2012-08-31