Irinotecan (CPT-11)

DRUG11 trials

Conditions

CholangiocarcinomaColon CancerColorectal Adenocarcinoma Metastatic to the LiverColorectal CancerGastrointestinal CancerNeoplasmsPancreatic Adenocarcinoma Advanced or MetastaticPediatric Solid Tumor

Phase 1

A Phase I Study of Irinotecan (CPT-11) Administered as a Prolonged Infusion in Adult Patients With Solid Tumors

CompletedNCT00001495

National Cancer Institute (NCI)Neoplasms

Start: 1995-11-30End: 2000-10-31Target: 40Updated: 2008-03-04

UGT1A1 Genotype-drien Phase I Study of Irinotecan in VIT Regimen for the Treatment of Pediatric R/R Solid Tumors

RecruitingNCT06760117

Sun Yat-sen UniversityPediatric Solid Tumor

Start: 2022-01-01End: 2025-12-31Target: 39Updated: 2025-01-06

Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer

RecruitingNCT07056777

Zhejiang Doer Biologics Co., Ltd.Gastrointestinal Cancer

Start: 2025-03-25End: 2026-06-30Target: 186Updated: 2026-01-13

Phase 2

Oxaliplatin/CPT-11 for Extensive Stage Small Cell Lung Cancer

TerminatedNCT00316433

Swedish Medical CenterSmall Cell Lung Cancer

Start: 2005-02-28End: 2007-01-31Target: 24Updated: 2007-04-05

Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver

WithdrawnNCT03069950

Memorial Sloan Kettering Cancer CenterColorectal Adenocarcinoma Metastatic to the Liver

Start: 2017-02-28End: 2019-05-16Updated: 2019-05-21

A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma

CompletedNCT03693807

Memorial Sloan Kettering Cancer CenterCholangiocarcinoma, Colorectal Cancer

Start: 2018-10-18End: 2024-06-27Updated: 2026-02-06

A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma

NCT04668976

Benaroya Research InstituteCholangiocarcinoma, Colorectal Cancer

Start: 2020-11-25End: 2024-12-31Target: 100Updated: 2020-12-21

CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC

Not yet recruitingNCT06652412

Fudan UniversityColon Cancer, Rectal Cancer

Start: 2024-11-30End: 2028-11-30Target: 124Updated: 2024-10-28

Phase 3

FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab as 1st Line Treatment of pMMR and IS IC-High Metastatic Colorectal Cancer Patients.

RecruitingNCT06733038

Gruppo Oncologico del Nord-OvestColorectal Cancer

Start: 2024-11-15End: 2029-04-01Target: 238Updated: 2025-12-08

Gemcitabine Plus Nab-paclitaxel as Switch Maintenance Versus Continuation of Modified FOLFIRINOX as 1st Line Chemotherapy in Patients With Advanced Pancreatic Cancer.

RecruitingNCT06897644

Gruppo Oncologico del Nord-OvestPancreatic Adenocarcinoma Advanced or Metastatic

Start: 2025-03-27End: 2030-01-01Target: 340Updated: 2025-05-25

Phase 4

Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type RAS and AREG/EREG High Status

Not yet recruitingNCT07094893

Gruppo Oncologico del Nord-OvestColorectal Cancer

Start: 2026-04-15End: 2030-03-31Target: 280Updated: 2026-01-14

Related Papers

A phase III randomized clinical trial of Gemcitabine and Nab-Paclitaxel as switch maintenance versus continuation of modified FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: The PANThEON Study.

2025-11-28