Intravenous thrombolysis

DRUG13 trials

Sponsors

Insel Gruppe AG, University Hospital Bern, Mayo Clinic, University of Leicester, Changhai Hospital, The First Affiliated Hospital of University of Science and Technology of China

Conditions

Acute Cerebrovascular AccidentAcute Ischemic StrokeAlteplaseBasilar Artery OcclusionIschaemic StrokeIschemic StrokeLarge Vessel OcclusionPulmonary Embolism

Early Phase 1

Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke

Not yet recruitingNCT06760195

Capital Medical UniversityAcute Ischemic Stroke

Start: 2025-01-10End: 2025-06-30Target: 6Updated: 2025-01-07

Phase 2

Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke

TerminatedNCT01869478

Mayo ClinicIschemic Stroke, Stroke

Start: 2013-01-31End: 2015-09-30Updated: 2016-10-05

Phase 3

Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion

RecruitingNCT05827042

The First Affiliated Hospital of University of Science and Technology of ChinaAcute Cerebrovascular Accident, Basilar Artery Occlusion, Stroke Due to Basilar Artery Occlusion

Start: 2023-05-09End: 2026-03-31Target: 338Updated: 2024-10-01

Intravenous Thrombolysis and NOAC

RecruitingNCT06749834

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityAcute Ischemic Stroke

Start: 2025-01-27End: 2027-06-30Target: 280Updated: 2025-02-24

Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer

Not yet recruitingNCT06841965

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityAcute Ischemic Stroke, Stroke

Start: 2025-03-01End: 2027-12-31Target: 280Updated: 2025-02-24

Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months

Not yet recruitingNCT06841978

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityAcute Ischemic Stroke, Stroke

Start: 2025-03-01End: 2027-12-31Target: 306Updated: 2025-02-24

Unknown Phase

Swiss Intravenous and Intra-arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry

CompletedNCT00811538

Insel Gruppe AG, University Hospital BernIschemic Stroke

Start: 2007-12-31End: 2015-12-31Updated: 2016-04-13

Cerebral Haemodynamics in Stroke Thrombolysis Study (CHIST)

CompletedNCT02928926

University of LeicesterIschaemic Stroke

Start: 2016-04-30End: 2017-10-31Target: 22Updated: 2020-01-30

Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals

CompletedNCT03469206

Changhai HospitalAlteplase, Ischemic Stroke, Large Vessel Occlusion +2

Start: 2018-02-21End: 2019-10-26Updated: 2019-10-29

a Cohort Study of Ischemic Cerebrovascular Disease

RecruitingNCT05922540

Xiangya Hospital of Central South UniversityIschaemic Stroke

Start: 2022-11-01End: 2027-11-01Target: 5000Updated: 2023-06-28

Registration of Intravenous Thrombolysis for Acute Ischemic Stroke in Southwestern China（IVTIS）

RecruitingNCT06131385

Zhengzhou YuanStroke, Acute

Start: 2023-11-20End: 2046-05-01Target: 3000Updated: 2023-11-28

Mechanical Thrombectomy With the FlowTriever Device in Acute Pulmonary Embolism - a Retrospective Analysis

CompletedNCT06187987

Kristina SvennerholmPulmonary Embolism

Start: 2023-04-01End: 2025-03-31Updated: 2025-05-20

Extending the Time Window for Intravenous Tenecteplase in Patients With Distal Medium Vessel Occlusions Stroke

RecruitingNCT06559436

The First Affiliated Hospital of University of Science and Technology of ChinaAcute Ischemic Stroke

Start: 2024-10-02End: 2026-12-01Target: 560Updated: 2024-10-24

Related Papers

Asymptomatic Hemorrhagic Events and Functional Outcomes in Acute Stroke

JAMA Network Open2025-03-283 citations

Impact of anesthesia modalities on functional outcome of mechanical thrombectomy in patients with acute ischemic stroke: a subgroup analysis of DIRECT-MT trial

European journal of medical research2023-07-1075 citations

Mild and moderate cardioembolic stroke patients may benefit more from direct mechanical thrombectomy than bridging therapy: A subgroup analysis of a randomized clinical trial (DIRECT-MT)

Frontiers in Neurology2022-11-247 citations

Early diagnosis of intracranial atherosclerotic large vascular occlusion: A prediction model based on DIRECT-MT data

Frontiers in Neurology2022-11-037 citations

Effect of Admission Hyperglycemia on Safety and Efficacy of Intravenous Alteplase Before Thrombectomy in Ischemic Stroke: Post-hoc Analysis of the DIRECT-MT trial.

2022-09-234 citations

Baseline blood pressure does not modify the effect of intravenous thrombolysis in successfully revascularized patients

Frontiers in Neurology2022-09-122 citations

CT Hyperdense Artery Sign and the Effect of Alteplase in Endovascular Thrombectomy after Acute Stroke

Radiology2022-07-1222 citations

Predictors and outcome of early neurological deterioration after endovascular thrombectomy: a secondary analysis of the DIRECT-MT trial

Journal of NeuroInterventional Surgery2022-06-1032 citations

Association of Intravenous Alteplase, Early Reperfusion, and Clinical Outcome in Patients With Large Vessel Occlusion Stroke: Post Hoc Analysis of the Randomized DIRECT-MT Trial

Stroke2022-03-0428 citations

Predictors of mortality in acute ischemic stroke treated with endovascular thrombectomy despite successful reperfusion: subgroup analysis of a multicentre randomised clinical trial

BMJ Open2022-03-0115 citations

Patient-Reported Anxiety/Depression After Endovascular Thrombectomy: A post-hoc Analysis of Direct-MT Trial

Frontiers in Neurology2022-02-093 citations

Effect of stroke etiology on endovascular thrombectomy with or without intravenous alteplase: a subgroup analysis of DIRECT-MT

Journal of NeuroInterventional Surgery2022-01-115 citations

Effect of Occlusion Site on the Safety and Efficacy of Intravenous Alteplase Before Endovascular Thrombectomy: A Prespecified Subgroup Analysis of DIRECT-MT

Stroke2021-12-1721 citations

Clinical and Imaging Indicators of Hemorrhagic Transformation in Acute Ischemic Stroke After Endovascular Thrombectomy

Stroke2021-12-0782 citations

Is concurrent intravenous alteplase in patients undergoing endovascular treatment for large vessel occlusion stroke cost-effective even if the cost of alteplase is only US$1?

Journal of NeuroInterventional Surgery2021-06-2916 citations

MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion-study protocol for a randomized clinical trial.

2021-02-1545 citations

Impact of EMS bypass to endovascular capable hospitals: geospatial modeling analysis of the US STRATIS registry

Journal of NeuroInterventional Surgery2020-05-0826 citations

Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke

New England Journal of Medicine2020-05-06796 citations