Intrathecal Triple Therapy

DRUG2 trials

Sponsors

St. Jude Children's Research Hospital

Conditions

Acute Lymphoblastic Leukemia With Failed RemissionAcute Lymphoblastic Leukemia, in RelapseAcute Myeloid Leukemia

Phase 1

Study of Venetoclax in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Leukemia of Ambiguous Lineage

CompletedNCT03194932

St. Jude Children's Research HospitalAcute Myeloid Leukemia

Start: 2017-07-11End: 2022-06-22Updated: 2023-02-14

Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia

TerminatedNCT03515200

St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia With Failed Remission

Start: 2018-04-20End: 2020-07-29Updated: 2020-09-01

Related Papers

Venetoclax in combination with cytarabine with or without idarubicin or azacitidine in children, adolescents, and young adults with relapsed or refractory acute myeloid leukaemia (VENAML): a multicentre, phase 1 expansion study.

2026-07-08

Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukemia: A multi-center phase II expansion study

Blood2025-11-03

Relapsed acute lymphoblastic leukemia treated with venetoclax and navitoclax: Results of the raven study in children and young adults with relapsed/ refractory ALL

Blood2025-11-03

Dosing of Venetoclax in Pediatric Patients with Relapsed Acute Myeloid Leukemia: Analysis of Developmental Pharmacokinetics and Exposure-Response Relationships.

2024-10-053 citations

Preliminary Safety and Efficacy of Venetoclax and Selinexor in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia: Selclax

Blood2023-11-022 citations

ITCC-101/APAL2020D: A Randomized Phase 3 Trial of Fludarabine/Cytarabine/Gemtuzumab Ozogamycin with or without Venetoclax in Children with Relapsed Acute Myeloid Leukemia

Blood2022-11-156 citations

Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.

2020-03-11125 citations

Metabolic Acidosis in a Pediatric Patient with Leukemia and Fungal Infection

Clinical Chemistry2020-01-035 citations

Safety and activity of venetoclax in combination with high-dose cytarabine in children with relapsed or refractory acute myeloid leukemia.

Journal of Clinical Oncology2019-05-203 citations