intraoperative radiotherapy

RADIATION19 trials

Sponsors

Radiation Therapy Oncology Group, University of Southern California, Hoag Memorial Hospital Presbyterian, Universitätsmedizin Mannheim, Peter MacCallum Cancer Centre, Australia

Conditions

Borderline Resectable Pancreatic CancerBrain MetastasesBrain Metastases, AdultBreast CancerBreast Cancer Stage IBreast Cancer Stage IIABreast Cancer, Invasive DuctalBreast Diseases

Phase 2

Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma

WithdrawnNCT00017160

Radiation Therapy Oncology GroupRecurrent Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma, Stage IIC Adult Soft Tissue Sarcoma +2

Updated: 2013-06-27

Kypho-IORT: Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases

CompletedNCT01280032

Universitätsmedizin MannheimTumors

Start: 2011-01-31End: 2013-07-31Target: 18Updated: 2022-07-22

A Prospective Single Arm Study of Intraoperative Radiotherapy for Locally Advanced or Recurrent Rectal Cancer

CompletedNCT01493206

Peter MacCallum Cancer Centre, AustraliaMalignant Rectal Neoplasm, Recurrent Tumor

Start: 2004-07-31End: 2011-08-31Updated: 2025-05-31

Focal Intraoperative Radiotherapy of Brain Metastases

TerminatedNCT03789149

AC Camargo Cancer CenterBrain Metastases, Adult, Central Nervous System Metastases

Start: 2019-05-02End: 2022-06-30Updated: 2023-07-27

IORT on Borderline Resectable Pancreatic Cancer

SuspendedNCT04090463

Universita di VeronaBorderline Resectable Pancreatic Cancer

Start: 2019-10-01End: 2027-12-30Target: 100Updated: 2024-05-07

Phase 3

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Active, not recruitingNCT02685605

Universitätsmedizin MannheimGlioblastoma

Start: 2016-12-09End: 2026-06-30Updated: 2025-10-14

Unknown Phase

Targeted Intra-Operative Radiotherapy for the Management of Ductal Carcinoma In-Situ of the Breast

TerminatedNCT00556907

University of Southern CaliforniaBreast Cancer

Start: 2007-10-31End: 2016-11-30Updated: 2025-11-06

Intraoperative Radiotherapy for Early Stage Breast Cancer

CompletedNCT01189851

Hoag Memorial Hospital PresbyterianBreast Cancer

Start: 2010-06-30End: 2023-12-31Target: 200Updated: 2024-10-15

Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer

CompletedNCT01299987

Universitätsmedizin MannheimBreast Diseases, Breast Neoplasms, Neoplasm Recurrence, Local +1

Start: 2011-01-31End: 2022-11-30Updated: 2025-03-30

Single Fraction Intraoperative Radiotherapy

CompletedNCT01688388

St. Joseph Hospital of OrangeInvasive Ductal and Invasive Lobular Breast Carcinoma, Stage 0 Breast Carcinoma, Stage I Breast Carcinoma +1

Start: 2012-02-29End: 2022-02-28Updated: 2022-05-11

Randomized Trial on Intraoperative Radiotherapy Full Dose Vs External Radiotherapy

CompletedNCT01849133

European Institute of OncologyCarcinoma Breast

Start: 2000-11-30End: 2012-12-31Updated: 2013-05-08

Comparison of Intra-operative Radiotherapy With Post-operative Radiotherapy for Women With Ductal Carcinoma in Situ

Liao NingBreast Neoplasms

Start: 2014-06-30End: 2024-06-30Target: 74Updated: 2015-03-17

Intra-operative Radiotherapy For Women With Ductal Carcinoma in Situ Breast Cancer

RecruitingNCT02389673

Liao NingBreast Neoplasms

Start: 2014-10-31End: 2026-06-30Target: 222Updated: 2015-03-17

Intraoperative Radiotherapy After the Resection of Brain Metastases

Universitätsmedizin MannheimBrain Metastases

Start: 2017-03-28End: 2023-12-31Target: 50Updated: 2022-06-03

Intraoperative Electron Radiotherapy for Low-risk Early Breast Cancer

RecruitingNCT03838419

University Hospital HeidelbergBreast Cancer

Start: 2019-10-01End: 2032-01-01Target: 202Updated: 2026-03-10

Xoft® Intraoperative Radiotherapy (IORT) for Patients With Early-Stage Breast Cancer

TerminatedNCT04088435

University of LouisvilleBreast Cancer, Breast Cancer, Invasive Ductal, Breast Cancer Stage I +2

Start: 2019-09-10End: 2022-06-05Updated: 2023-05-12

Comparison Between IORT and Postoperative Radiotherapy in Breast Conserving Surgery

TerminatedNCT04789889

Xiangyun ZongQuality of Life

Start: 2021-03-01End: 2025-02-28Updated: 2025-06-02

Intraoperative Radiotherapy in Patients With Brain Metastases

RecruitingNCT04847284

Parc de Salut MarBrain Metastases

Start: 2021-05-05End: 2025-12-31Target: 25Updated: 2025-06-06

Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.

TerminatedNCT05289466

Saint John's Cancer InstituteIORT-Intra-Operative Radiation Therapy

Start: 2021-12-16End: 2024-10-23Updated: 2025-12-31

Related Papers

Intraoperative radiotherapy in elderly patients with breast cancer: long-term follow-up results of the prospective phase II trial TARGIT-E.

2025-12-04

OS06.1.A INTRAOPERATIVE RADIOTHERAPY AFTER RESECTION OF BRAIN METASTASES (INTRAMET)- FINAL RESULTS OF A PROSPECTIVE, SINGLE-ARM, OPEN-LABEL PHASE 2 TRIAL

Neuro-Oncology2025-10-01

Efficacy and Safety of Intraoperative Radiotherapy for High-Grade Gliomas: A Systematic Review and Meta-Analysis.

2024-01-154 citations

INTRAMET: Results of a prospective, single-arm, open-label phase II trial of intraoperative radiotherapy after resection of brain metastases.

Journal of Clinical Oncology2023-06-016 citations

NIMG-74. RESPONSE ASSESSMENT AFTER DOSE-ESCALATED RADIOTHERAPY: IMAGING PROTOCOL OF A MULTICENTER PHASE III TRIAL ON INTRAOPERATIVE RADIOTHERAPY IN NEWLY DIAGNOSED GLIOBLASTOMA (INTRAGO-II;ARO2016-1;AG-NRO-03)

Neuro-Oncology2021-11-02

Intraoperative irradiation for early breast cancer (ELIOT): long-term recurrence and survival outcomes from a single-centre, randomised, phase 3 equivalence trial.

2021-04-09134 citations

A phase II trial proposal of total neoadjuvant treatment with primary chemotherapy, stereotactic body radiation therapy, and intraoperative radiation therapy in borderline resectable pancreatic adenocarcinoma.

2021-02-164 citations

Long-term outcome after combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) for vertebral tumors

Radiation Oncology2020-11-1214 citations

Fatigue following radiotherapy of low-risk early breast cancer - a randomized controlled trial of intraoperative electron radiotherapy versus standard hypofractionated whole-breast radiotherapy: the COSMOPOLITAN trial (NCT03838419).

2020-06-013 citations

TARGIT E(lderly): Prospective phase II trial of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer.

Journal of Clinical Oncology2019-05-206 citations

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial.

2019-01-0143 citations

NIMG-56. CHARACTERISTIC RESPONSE PATTERNS IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA AFTER TREATMENT WITH HIGH SINGLE DOSES OF RADIOTHERAPY

Neuro-Oncology2017-11-01

Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases.

2017-09-2814 citations

TARGIT E(lderly): Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer—3 year local control and overall survival.

Journal of Clinical Oncology2017-05-201 citations

RTHP-05. INTRAOPERATIVE RADIOTHERAPY (IORT) USING LOW-ENERGY X-RAYS IN A COHORT OF PREDOMINANTLY INCOMPLETELY RESECTED NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME (INTRAGO TRIAL)

Neuro-Oncology2016-11-011 citations

TARGIT E(lderly): Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer.

Journal of Clinical Oncology2016-05-202 citations

TARGIT E(lderly) – Prospective phase II study of Intraoperative Radiotherapy (IORT) in elderly patients with small breast cancer

Senologie - Zeitschrift für Mammadiagnostik und -therapie2016-04-263 citations

Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.

2013-11-11511 citations

TARGIT-E(lderly)--prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer.

2012-05-0827 citations