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Intraoperative radiation therapy (IORT)

RADIATION5 trials

Sponsors

M.D. Anderson Cancer Center, University Hospital Heidelberg, Eileen Connolly, Gangnam Severance Hospital, Saint John's Cancer Institute

Conditions

Breast Carcinoma in SituBreast NeoplasmsEarly-stage Breast CancerResectable Pancreatic AdenocarcinomaRetroperitoneal Soft Tissue SarcomaSarcomaTriple Negative Breast Cancer

Phase 1

Radiation Therapy Plus Doxorubicin in Treating Patients With Resectable Primary or Recurrent Retroperitoneal Soft Tissue Sarcoma
CompletedNCT00004123
M.D. Anderson Cancer CenterSarcoma
Start: 1997-07-31End: 2009-10-31Updated: 2012-07-30
Trial of Neoadjuvant Intensity-Modulated Radiation Therapy Followed by Surgery and Intraoperative Radiation Therapy in Resectable Retroperitoneal Soft Tissue Sarcoma (RETRO-WTS)
CompletedNCT01566123
University Hospital HeidelbergRetroperitoneal Soft Tissue Sarcoma
Start: 2007-03-31End: 2020-02-29Target: 37Updated: 2020-04-03
Effects of MK-3475 (Pembrolizumab) on the Breast Tumor Microenvironment in Triple Negative Breast Cancer
RecruitingNCT02977468
Eileen ConnollyTriple Negative Breast Cancer
Start: 2017-10-25End: 2025-12-31Target: 15Updated: 2024-06-20

Unknown Phase

Intraoperative Radiation Therapy for Resectable Pancreatic Cancer
CompletedNCT03273374
Gangnam Severance HospitalResectable Pancreatic Adenocarcinoma
Start: 2017-08-14End: 2022-08-22Updated: 2023-09-13
Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer
RecruitingNCT04603209
Saint John's Cancer InstituteBreast Carcinoma in Situ, Breast Neoplasms, Early-stage Breast Cancer
Start: 2018-10-03End: 2028-10-03Target: 1000Updated: 2024-04-16

Related Papers

Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial
Cancers2023-05-139 citations
Intraoperative Radiotherapy for Resectable Pancreatic Cancer Using a Low-Energy X-Ray Source: Postoperative Complications and Early Outcomes
Yonsei Medical Journal2022-01-018 citations
Intraoperative radiation therapy induces immune response activity after pancreatic surgery.
2021-10-129 citations
Abstract P3-09-17: Preoperative pembrolizumab increases sTILs in treatment naïve stage I/IIA TNBC patients in a window of opportunity trial
Cancer Research2020-02-15
A phase II study of intraoperative radiotherapy using a low-energy x-ray source for resectable pancreatic cancer: a study protocol.
2019-03-072 citations
Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis.
2014-08-2763 citations
A clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma.
2012-07-1227 citations