intramuscular benzathine penicillin G (BPG) prophylaxis

DRUG2 trials

Sponsors

Children's National Research Institute, Children's Hospital Medical Center, Cincinnati

Conditions

Heart DiseasesLatent Rheumatic Heart DiseaseRheumatic Heart DiseaseRheumatic Heart Disease in Children

Phase 2

Determining the Impact of Penicillin in Latent RHD: The GOAL Trial

Children's National Research InstituteHeart Diseases, Latent Rheumatic Heart Disease, Rheumatic Heart Disease +1

Start: 2018-06-26End: 2020-11-30Updated: 2019-10-01

GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial

Active, not recruitingNCT05693545

Children's Hospital Medical Center, CincinnatiRheumatic Heart Disease

Start: 2023-09-01End: 2027-09-30Target: 1004Updated: 2026-03-17

Related Papers

Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial).

2024-05-241 citations

Abstract 12503: A Randomized Controlled Trial of Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Circulation2021-11-163 citations

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

New England Journal of Medicine2021-11-13150 citations

The inter-rater reliability and individual reviewer performance of the 2012 world heart federation guidelines for the echocardiographic diagnosis of latent rheumatic heart disease.

2020-11-1010 citations

Determining the impact of Benzathine penicillin G prophylaxis in children with latent rheumatic heart disease (GOAL trial): Study protocol for a randomized controlled trial.

2019-06-0824 citations

OC02_08 Validation of the World Heart Federation Evidence-Based Echocardiographic Criteria for Rheumatic Heart Disease

Global Heart2016-06-01