Intraarterial alteplase

DRUG2 trials

Sponsors

Hospital Clinic of Barcelona

Conditions

Stroke, AcuteStroke, Acute Ischemic

Phase 2

Intraarterial Alteplase Versus Placebo After Mechanical Thrombectomy

CompletedNCT03876119

Hospital Clinic of BarcelonaStroke, Acute

Start: 2018-12-05End: 2021-05-31Updated: 2022-05-20

Phase 3

CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).

CompletedNCT05797792

Hospital Clinic of BarcelonaStroke, Acute, Stroke, Acute Ischemic

Start: 2023-11-18End: 2025-11-14Updated: 2026-09-18

Related Papers

Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke

JAMA2026-05-07

Natural Evolution of Incomplete Reperfusion in Patients Following Endovascular Therapy After Ischemic Stroke.

2024-11-203 citations

Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial

BMJ Open2024-11-0123 citations

Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke

JAMA2022-02-10323 citations