Internal Radiation Therapy

RADIATION15 trials

Sponsors

Gynecologic Oncology Group, National Cancer Institute (NCI), GOG Foundation, Albert Einstein College of Medicine, Stanford University

Conditions

AnemiaCervical AdenocarcinomaCervical Adenosquamous CarcinomaCervical CancerCervical Small Cell CarcinomaCervical Squamous Cell CarcinomaCervical Squamous Cell Carcinoma, Not Otherwise SpecifiedDrug Toxicity

Phase 1

Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer

CompletedNCT00068549

Gynecologic Oncology GroupCervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Small Cell Carcinoma +6

Start: 2003-10-31Updated: 2014-12-25

Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer

CompletedNCT00104910

Gynecologic Oncology GroupCervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Small Cell Carcinoma +6

Start: 2005-01-31Updated: 2014-12-31

Cisplatin and Radiation Therapy Followed by Paclitaxel and Carboplatin in Treating Patients With Stage IB-IVA Cervical Cancer

Gynecologic Oncology GroupCervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified +6

Start: 2011-04-04Target: 45Updated: 2019-03-12

Chemoradiation Therapy and Ipilimumab in Treating Patients With Stages IB2-IIB or IIIB-IVA Cervical Cancer

CompletedNCT01711515

National Cancer Institute (NCI)Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified +6

Start: 2012-10-01End: 2020-07-17Updated: 2020-09-02

MRI-Guided Brachytherapy in Treating Participants With HPV-Associated Stage IB2-IVA Cervical or Stage II-IVA Vaginal Cancer

Active, not recruitingNCT03634267

M.D. Anderson Cancer CenterHuman Papillomavirus-Related Carcinoma, Human Papillomavirus-Related Cervical Carcinoma, Stage IB2 Cervical Cancer AJCC v8 +14

Start: 2018-08-03End: 2026-12-31Updated: 2025-10-14

Phase 2

Bevacizumab, Radiation Therapy, and Cisplatin in Treating Patients With Previously Untreated Locally Advanced Cervical Cancer

CompletedNCT00369122

National Cancer Institute (NCI)Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified +4

Start: 2006-08-11End: 2016-12-15Updated: 2018-03-20

Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial Cancer

GOG FoundationEndometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation, Endometrial Mucinous Adenocarcinoma, Endometrial Squamous Cell Carcinoma +5

Start: 2008-02-25Updated: 2023-03-29

Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Endometrial Cancer

TerminatedNCT01041027

Albert Einstein College of MedicineEndometrial Adenocarcinoma, Stage IA Uterine Corpus Cancer, Stage IB Uterine Corpus Cancer +6

Start: 2009-01-16End: 2019-10-01Updated: 2023-10-26

Phase II Clinical Trial of Concurrent Chemoradiotherapy Combined Nimotuzumab for Stage IIB-IVA Cervical Cancer

Air Force Military Medical University, ChinaCervical Cancer

Start: 2015-09-30End: 2018-09-30Target: 60Updated: 2016-03-10

Brachytherapy With Durvalumab or Tremelimumab for the Treatment of Patients With Platinum-Resistant, Refractory, Recurrent, or Metastatic Gynecological Malignancies

Active, not recruitingNCT04395079

Jonsson Comprehensive Cancer CenterMetastatic Malignant Female Reproductive System Neoplasm, Platinum-Resistant Malignant Female Reproductive System Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm +1

Start: 2020-08-07End: 2026-12-01Updated: 2026-02-09

Phase 3

Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia

CompletedNCT00017004

Gynecologic Oncology GroupAnemia, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma +6

Start: 2001-08-31Updated: 2017-08-09

Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer

Gynecologic Oncology GroupEndometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Fatigue +4

Start: 2009-03-23Updated: 2019-03-20

Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer

Gynecologic Oncology GroupEndometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Stage IA Uterine Corpus Cancer AJCC v7 +6

Start: 2009-06-29End: 2024-07-28Updated: 2021-10-19

Unknown Phase

Gemcitabine Hydrochloride, Docetaxel, and Radiation Therapy in Treating Patients With Uterine Sarcoma That Has Been Removed By Surgery

TerminatedNCT01958580

Albert Einstein College of MedicineStage IA Uterine Sarcoma, Stage IB Uterine Sarcoma, Stage IC Uterine Sarcoma +8

Start: 2013-09-17End: 2017-02-24Updated: 2023-08-16

High-Dose Brachytherapy in Treating Patients With Prostate Cancer

Active, not recruitingNCT02346253

Stanford UniversityProstate Adenocarcinoma, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer +2

Start: 2015-01-13End: 2026-05-17Updated: 2025-04-03

Related Papers

Iterative intraoperative 3T MRI (iMRI)-guided brachytherapy: A prospective study on enhancing implantation precision and dosimetric gains in advanced gynecologic cancers.

2025-08-14

Molecular classification of endometrial cancers (EC) and association with relapse-free survival (RFS) and overall survival (OS) outcomes: Ancillary analysis of GOG-0258.

2025-01-239 citations

SO018/#362 Molecular classification of endometrial cancers (EC) and association with relapse-free survival (RFS) outcomes: ancillary analysis of GOG-0258

2023-11-015 citations

Patient reported outcomes for cisplatin and radiation followed by carboplatin/paclitaxel versus carboplatin/paclitaxel for locally advanced endometrial carcinoma: An NRG oncology study.

2021-12-114 citations

Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer

New England Journal of Medicine2019-06-12443 citations

Analysis of patient-reported outcomes (PROs) for GOG-258, a randomized phase III trial of cisplatin and tumor volume directed irradiation followed by carboplatin and paclitaxel (Cis-RT+CP) vs. carboplatin and paclitaxel (CP) for optimally debulked, locally advanced endometrial carcinoma: A Gynecologic Oncology Group/NRG study.

Journal of Clinical Oncology2018-05-207 citations

Quality of life (QoL) in a phase III trial of pelvic external beam radiation therapy (PXRT) versus vaginal cuff brachytherapy followed by paclitaxel/carboplatin chemotherapy (VCB/C) in patients with high risk, early stage endometrial carcinoma: An NRG Oncology/Gynecologic Oncology Group study.

Journal of Clinical Oncology2018-05-20

A randomized phase III trial of cisplatin and tumor volume directed irradiation followed by carboplatin and paclitaxel vs. carboplatin and paclitaxel for optimally debulked, advanced endometrial carcinoma.

Journal of Clinical Oncology2017-05-2070 citations

A phase I study of sequential ipilimumab in the definitive treatment of node positive cervical cancer: GOG 9929.

Journal of Clinical Oncology2017-05-2031 citations

Advances in Cervical Cancer

Oncology Times2016-12-25