IMRT and concurrent cisplatin

RADIATION4 trials

Sponsors

Sun Yat-sen University, Chaosu Hu, West China Hospital

Conditions

Nasopharyngeal Carcinoma

Phase 3

Induction Gemcitabine and Cisplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

Sun Yat-sen UniversityNasopharyngeal Carcinoma

Start: 2013-11-30End: 2020-11-30Updated: 2018-04-24

Sequential or Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced NPC

Chaosu HuNasopharyngeal Carcinoma

Start: 2018-01-01End: 2024-12-30Target: 420Updated: 2022-03-04

Induction Chemotherapy Plus Radiotherapy Alone in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

West China HospitalNasopharyngeal Carcinoma

Start: 2020-06-01End: 2025-05-30Target: 562Updated: 2020-06-04

Phase III Trial of Concurrent Chemotherapy Alone in Patients With Low-risk Nasopharyngeal Carcinoma

Active, not recruitingNCT05979961

Sun Yat-sen UniversityNasopharyngeal Carcinoma

Start: 2023-09-07End: 2031-03-05Updated: 2026-08-12

Related Papers

Sequential vs Induction Plus Concurrent Chemoradiotherapy in Nasopharyngeal Carcinoma

JAMA Oncology2025-07-244 citations

Sequential chemoradiotherapy versus induction chemotherapy plus concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: A multicentre, open-label, non-inferiority, randomised, phase 3 trial.

Journal of Clinical Oncology2024-06-01

The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment.

2023-06-0676 citations

Radiotherapy interruption due to holidays adversely affects the survival of patients with nasopharyngeal carcinoma: a joint analysis based on large-scale retrospective data and clinical trials

Radiation Oncology2022-02-1911 citations

Differential benefit of induction chemotherapy according to body mass index in nasopharyngeal carcinoma - Pooled analysis of two randomized trials.

2022-01-18

Identifying optimal clinical trial candidates for locoregionally advanced nasopharyngeal carcinoma: Analysis of 9468 real-world cases and validation by two phase 3 multicentre, randomised controlled trial.

2021-12-2819 citations

Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959).

2019-10-2359 citations

Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma

New England Journal of Medicine2019-05-31889 citations

Gemcitabine and cisplatin (GP) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) versus CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC): A phase 3, multicenter, randomized controlled trial.

Journal of Clinical Oncology2019-05-203 citations

Induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma

Chinese Journal of Cancer2016-11-1520 citations