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Imipenem-cilastatin

DRUG5 trials

Sponsors

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Pfizer, GlaxoSmithKline, Entasis Therapeutics, Spero Therapeutics

Conditions

AbscessAcute PyelonephritisCellulitisComplicated Urinary Tract InfectionInfections, Urinary TractSkin InfectionUrinary Tract InfectionVentilator-Associated Pneumonia

Phase 2

GSK2251052 in Complicated Urinary Tract Infection
TerminatedNCT01381549
GlaxoSmithKlineInfections, Urinary Tract
Start: 2011-06-28End: 2012-03-06Updated: 2017-09-08
Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections
CompletedNCT03445195
Entasis TherapeuticsAcute Pyelonephritis, Complicated Urinary Tract Infection
Start: 2018-01-17End: 2018-05-17Updated: 2020-01-22

Phase 3

To Compare Safety and Efficacy of Doripenem Versus Imipenem-Cilastatin in Patients With Ventilator-Associated Pneumonia
TerminatedNCT00589693
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.Ventilator-Associated Pneumonia
Start: 2008-04-30End: 2011-06-30Updated: 2012-12-28
Complicated Skin and Skin Structure Infections
CompletedNCT00619710
PfizerAbscess, Cellulitis, Skin Infection
Start: 2001-02-28End: 2004-04-30Target: 1000Updated: 2017-09-01
A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
CompletedNCT06059846
Spero TherapeuticsAcute Pyelonephritis, Urinary Tract Infection
Start: 2023-12-21End: 2025-02-06Updated: 2026-03-10

Related Papers

173. Oral Tebipenem Pivoxil Hydrobromide versus Intravenous Imipenem-Cilastatin in Patients with Complicated Urinary Tract Infections or Acute Pyelonephritis: Efficacy and Safety Results from the Phase 3 PIVOT-PO study
Open Forum Infectious Diseases2026-01-01
Pharmacokinetics and Tolerability of Intravenous Sulbactam-Durlobactam with Imipenem-Cilastatin in Hospitalized Adults with Complicated Urinary Tract Infections, Including Acute Pyelonephritis.
2020-02-2150 citations
Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections
Antimicrobial Agents and Chemotherapy2014-10-2897 citations
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia.
2012-11-13148 citations