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IMBRUVICA 140 mg hard capsules

DRUG20 trials

Sponsors

University Of Cologne, University Hospital Of Ulm AöR, Kite Pharma Inc., Incyte Corp., Universitatsmedizin der Johannes Gutenberg-Universitat Mainz KöR

Conditions

Advanced malignancies and IAI diseasesB-cell Non-Hodgkin's lymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaHigh Risk Chronic Lymphocytic LeukaemiaMantle Cell LymphomaMantle Cell Lymphoma (MCL)Previously untreated and symptomatic patients with histologically proven CD20-positive marginal zone B-cell lymphoma (MZL) in need of systemic treatmentRelapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL).

Phase 1

Phase 2

INCB 50465-801: A Phase 2, Open-Label, Multicenter, Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Parsaclisib (INCB050465)
RecruitingCTIS2022-501687-18-00
Incyte Corp.Advanced malignancies and IAI diseases
Start: 2020-10-28Target: 62Updated: 2025-07-07
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA-25) – Substudy A – Relapsed/Refractory Waldenstrom Macroglobulinemia
CompletedCTIS2022-501259-10-00
Kite Pharma Inc.Relapsed/Refractory Waldenstrom Macroglobulinemia (WM)
Start: 2023-04-14End: 2023-06-21Target: 37Updated: 2023-05-26
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy B – Relapsed/Refractory Richter Transformation (RT)
CompletedCTIS2022-501260-18-00
Kite Pharma Inc.Relapsed/refractory Richter Transformation (RT)
Start: 2023-04-14End: 2025-01-27Target: 35Updated: 2025-02-21
A Phase II study evaluating efficacy of KTE-X19 CAR-T cell therapy in Relapsed or Refractory Mantle-Cell Lymphoma achieving a partial response during Ibrutinib salvage therapy
RecruitingCTIS2022-502907-31-00
Fondazione IRCCS Istituto Nazionale Dei TumoriRelapsed or Refractory Mantle-Cell Lymphoma
Start: 2023-12-28Target: 20Updated: 2025-01-16
Venetoclax in combination with the BTK inhibitor Ibrutinib and Rituximab or conventional chemotherapy (Bendamustine) and Ibrutinib and Rituximab in patients with treatment naive Mantle Cell Lymphoma not eligible for high dose therapy
RecruitingCTIS2022-501808-96-00
Universitatsmedizin der Johannes Gutenberg-Universitat Mainz KöRMantle Cell Lymphoma
Start: 2023-05-15Target: 200Updated: 2026-01-19
A Randomized, Controlled, Open-label, Multicenter, Inferentially Seamless Phase 2/3 Study of Ibrutinib in Combination With Rituximab Versus Physician’s Choice of Lenalidomide Plus Rituximab or Bortezomib Plus Rituximab in Participants with Relapsed or Refractory Mantle Cell Lymphoma
CompletedCTIS2023-503618-64-00
Janssen - Cilag InternationalRelapsed/Refractory Mantle Cell Lymphoma
Start: 2022-11-16End: 2024-09-18Target: 7Updated: 2024-04-24
Multicohort Study to Customize Ibrutinib Treatment Regimens for Patients with Previously Untreated Chronic Lymphocytic Leukemia
RecruitingCTIS2023-504044-34-00
Janssen - Cilag InternationalUntreated Chronic Lymphocytic Leukemia
Start: 2024-04-17Target: 213Updated: 2026-01-19
A Phase 2 Multicenter Study Evaluating the Efficacy of KTE-X19 in Subjects with Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)
CompletedCTIS2023-506641-35-00
Kite Pharma Inc.Relapsed/Refractory Mantle Cell Lymphoma
Start: 2018-07-09End: 2025-06-17Target: 68Updated: 2025-03-10
MALIBU trial - Phase II study of combination ibrutinib and rituximab in untreated marginal zone lymphomas
Active, not recruitingCTIS2023-507886-25-00
Association International Extranodal Lymphoma Study Group (IELSG)Previously untreated and symptomatic patients with histologically proven CD20-positive marginal zone B-cell lymphoma (MZL) in need of systemic treatment
Start: 2019-09-27Target: 178Updated: 2025-06-30
Multicentric phase II trial to evaluate the efficacy and safety of Ibrutinib in combination with rituximab in patients with indolent clinical forms of Mantle Cell Lymphoma.
Not yet recruitingCTIS2024-512370-94-00
Fundacion GeltamoMantle Cell Lymphoma
Target: 50Updated: 2025-12-12
HOVON 141 CLL: A prospective, multicenter, phase-II trial of ibrutinib plus venetoclax in patients with creatinine clearance ≥ 30 ml/min who have relapsed or refractory chronic lymphocytic leukemia (RR-CLL) with or without TP53 aberrations.
Active, not recruitingCTIS2023-510557-42-00
Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichtingchronic lymphocytic leukemia
Start: 2017-07-10Target: 230Updated: 2024-07-16
Early treatment intensification in patients with high risk Mantle Cell Lymphoma using CAR-T-cell treatment after an abbreviated induction therapy with Rituximab and Ibrutinib and 6 months Ibrutinib maintenance (Arm A) as compared to standard of care induction and maintenance (Arm B)
RecruitingCTIS2022-502405-15-01
Klinikum Der Universitat Munchen AöRMantle Cell Lymphoma (MCL)
Start: 2024-04-08Target: 150Updated: 2026-01-22
ENRICH - Randomised, open label study of Rituximab/Ibrutinib vs Rituximab/Chemotherapy in older patients with untreated mantle cell lymphoma
Active, not recruitingCTIS2024-514275-18-00
Region Skane, University Hospitals Plymouth NHS TrustMantle Cell Lymphoma (MCL)
Start: 2017-12-06Target: 135Updated: 2025-09-22
Efficacy and safety of Carfilzomib in combination with Ibrutinib vs. Ibrutinib alone in Waldenström’s Macroglobulinemia (CZAR-1)
Active, not recruitingCTIS2024-511929-60-00
Universitaetsklinikum Ulm AöRWaldenström’s Macroglobulinemia
Start: 2021-01-28Target: 105Updated: 2025-06-25
Efficacy of first line Bortezomib, Rituximab, Ibrutinib (B-RI) for patients with treatment naive Waldenström’s Macroglobulinemia - A MULTICENTER OPEN LABEL, SINGLE ARM EUROPEAN PHASE II STUDY (ECWM-2)
Active, not recruitingCTIS2022-500584-12-00
University Hospital Of Ulm AöRWaldenström’s Macroglobulinemia
Start: 2019-09-11Target: 53Updated: 2025-10-09

Phase 3

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