IMBRUVICA 140 mg hard capsules
Sponsors
University Of Cologne, University Hospital Of Ulm AöR, Kite Pharma Inc., Incyte Corp., Universitatsmedizin der Johannes Gutenberg-Universitat Mainz KöR
Conditions
Advanced malignancies and IAI diseasesB-cell Non-Hodgkin's lymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaHigh Risk Chronic Lymphocytic LeukaemiaMantle Cell LymphomaMantle Cell Lymphoma (MCL)Previously untreated and symptomatic patients with histologically proven CD20-positive marginal zone B-cell lymphoma (MZL) in need of systemic treatmentRelapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL).
Phase 1
Phase 1b/2, Open-Label Study to Evaluate Safety and Tolerability of Epcoritamab in Combination with Anti-Neoplastic Agents in Subjects with Non-Hodgkin Lymphoma
RecruitingCTIS2023-505347-38-00
Start: 2022-06-13Target: 59Updated: 2025-11-21
A Phase Ib/II Study of APG-2575 as a Single Agent or in Combination with Other Therapeutic Agents in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (SACRED).
RecruitingCTIS2024-515654-25-00
Start: 2021-12-20Target: 60Updated: 2025-09-08
Phase 2
INCB 50465-801:
A Phase 2, Open-Label, Multicenter, Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Parsaclisib (INCB050465)
RecruitingCTIS2022-501687-18-00
Start: 2020-10-28Target: 62Updated: 2025-07-07
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA-25) – Substudy A – Relapsed/Refractory Waldenstrom Macroglobulinemia
CompletedCTIS2022-501259-10-00
Start: 2023-04-14End: 2023-06-21Target: 37Updated: 2023-05-26
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy B – Relapsed/Refractory Richter Transformation (RT)
CompletedCTIS2022-501260-18-00
Start: 2023-04-14End: 2025-01-27Target: 35Updated: 2025-02-21
A Phase II study evaluating efficacy of KTE-X19 CAR-T cell therapy in Relapsed or Refractory Mantle-Cell Lymphoma achieving a partial response during Ibrutinib salvage therapy
RecruitingCTIS2022-502907-31-00
Start: 2023-12-28Target: 20Updated: 2025-01-16
Venetoclax in combination with the BTK inhibitor Ibrutinib and Rituximab or conventional chemotherapy (Bendamustine) and Ibrutinib and Rituximab in patients with treatment naive Mantle Cell Lymphoma not eligible for high dose therapy
RecruitingCTIS2022-501808-96-00
Start: 2023-05-15Target: 200Updated: 2026-01-19
A Randomized, Controlled, Open-label, Multicenter, Inferentially Seamless Phase 2/3 Study of Ibrutinib in Combination With Rituximab Versus Physician’s Choice of Lenalidomide Plus Rituximab or Bortezomib Plus Rituximab in Participants with Relapsed or Refractory Mantle Cell Lymphoma
CompletedCTIS2023-503618-64-00
Start: 2022-11-16End: 2024-09-18Target: 7Updated: 2024-04-24
Multicohort Study to Customize Ibrutinib Treatment Regimens for Patients with Previously Untreated Chronic Lymphocytic Leukemia
RecruitingCTIS2023-504044-34-00
Start: 2024-04-17Target: 213Updated: 2026-01-19
A Phase 2 Multicenter Study Evaluating the Efficacy of KTE-X19 in Subjects with Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)
CompletedCTIS2023-506641-35-00
Start: 2018-07-09End: 2025-06-17Target: 68Updated: 2025-03-10
MALIBU trial - Phase II study of combination ibrutinib and rituximab in untreated marginal zone lymphomas
Active, not recruitingCTIS2023-507886-25-00
Start: 2019-09-27Target: 178Updated: 2025-06-30
Multicentric phase II trial to evaluate the efficacy and safety of Ibrutinib in combination with rituximab in patients with indolent clinical forms of Mantle Cell Lymphoma.
Not yet recruitingCTIS2024-512370-94-00
Target: 50Updated: 2025-12-12
HOVON 141 CLL: A prospective, multicenter, phase-II trial of ibrutinib plus venetoclax in patients with creatinine clearance ≥ 30 ml/min who have relapsed or refractory chronic lymphocytic leukemia (RR-CLL) with or without TP53 aberrations.
Active, not recruitingCTIS2023-510557-42-00
Start: 2017-07-10Target: 230Updated: 2024-07-16
Early treatment intensification in patients with high risk Mantle Cell Lymphoma using CAR-T-cell treatment after an abbreviated induction therapy with Rituximab and Ibrutinib and 6 months Ibrutinib maintenance (Arm A) as compared to standard of care induction and maintenance (Arm B)
RecruitingCTIS2022-502405-15-01
Start: 2024-04-08Target: 150Updated: 2026-01-22
ENRICH - Randomised, open label study of Rituximab/Ibrutinib vs Rituximab/Chemotherapy in older patients with untreated mantle cell lymphoma
Active, not recruitingCTIS2024-514275-18-00
Start: 2017-12-06Target: 135Updated: 2025-09-22
Efficacy and safety of Carfilzomib in combination with Ibrutinib vs. Ibrutinib alone in Waldenström’s Macroglobulinemia
(CZAR-1)
Active, not recruitingCTIS2024-511929-60-00
Start: 2021-01-28Target: 105Updated: 2025-06-25
Efficacy of first line Bortezomib, Rituximab, Ibrutinib (B-RI) for patients with treatment naive Waldenström’s Macroglobulinemia - A MULTICENTER OPEN LABEL, SINGLE ARM EUROPEAN PHASE II STUDY (ECWM-2)
Active, not recruitingCTIS2022-500584-12-00
Start: 2019-09-11Target: 53Updated: 2025-10-09
Phase 3
A phase 3 multicentre, randomized, prospective, open-label trial of Ibrutinib monotherapy versus fixed-duration Venetoclax plus Obinutuzumab versus fixed-duration Venetoclax plus Ibrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL) - CLL17
Active, not recruitingCTIS2022-500439-35-00
Start: 2021-02-11Target: 841Updated: 2025-12-03
A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects with High Risk Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509347-27-00
Start: 2015-09-30Target: 17Updated: 2025-09-30