Iclusig 15 mg film-coated tablets
Sponsors
Cardiff University, Fondazione Gimema Franco Mandelli Onlus, Fundacion Cris De Investigacion Para Vencer El Cancer, Incyte Biosciences International S.a.r.l., Assistance Publique Hopitaux De Paris
Conditions
Adult Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia.Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.Blood cancerCHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE OR IN MYELOID BLAST CRISISChronic Phase Chronic Myeloid LeukemiaChronic myelogenous leukemiaLymphomasPatients aged 18-65 years old with newly diagnosed previously untreated ALL or T-LL.
Phase 1
Phase 2
Multicenter, Open-Label, Single Arm, Phase II Exploratory Study to Evaluate the Reinduction and second stop of TKI with Ponatinib in CML in Molecular Response (ResToP)
CompletedCTIS2023-508993-27-00
Start: 2020-01-17End: 2026-01-12Target: 80Updated: 2025-08-18
Combination of Ponatinib Plus Chemotherapy As Frontline Treatment For Patients With BCR/ABL1-Like Acute Lymphoblastic Leukemia (BCR/ABL1-Like ALL) - BALLik. ALL2922
RecruitingCTIS2023-510240-20-00
Start: 2022-10-05Target: 32Updated: 2025-05-13
OPEN LABEL PHASE 2 STUDY ON THE EFFICACY AND TOLERANCE OF A COMBINATION OF PONATINIB AND 5-AZACITIDINE IN CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE OR IN MYELOID BLAST CRISIS
Active, not recruitingCTIS2024-516048-24-00
Start: 2019-06-19Target: 40Updated: 2026-01-05
Ponatinib for the management of minimal residual disease (MRD) and hematologic relapsein adult Ph+ acute lymphoblastic leukemia (Ph+ ALL) patients.ALL2620
Active, not recruitingCTIS2024-516868-28-00
Start: 2021-05-04Target: 67Updated: 2024-09-18
A Randomized, Open-label, Phase 2 Trial of Ponatinib in Patients with Resistant Chronic Phase Chronic Myeloid Leukemia to Characterize the Efficacy and Safety of a Range of Doses
CompletedCTIS2024-514516-27-00
Start: 2015-12-01End: 2025-04-23Target: 2Updated: 2025-02-25
GRAALL 2024 - A 3-cohort Randomized Study evaluating the role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults with Acute Lymphoblastic Leukemia
RecruitingCTIS2024-511437-35-00
Start: 2026-01-05Target: 1100Updated: 2025-11-20
With Ponatinib on the track for treatment-free-remission in chronic myeloid leukemia
Not yet recruitingCTIS2024-518971-76-00
Target: 17Updated: 2024-11-22
EWALL-PH-03: An open label, 2-arm, Randomised phase II study to Compare the Safety and Efficacy of Ponatinib plus Chemotherapy with Imatinib plus Chemotherapy as front-line therapy for patients aged 55 years and over with Philadelphia chromosome positive (Ph+ or BCR-ABL+) Acute Lymphoblastic Leukemia (ALL)
Not yet recruitingCTIS2023-505330-95-01
Target: 100Updated: 2025-10-08