Hypothermic oxygenated perfusion (HOPE)

DEVICE4 trials

Sponsors

University of Zurich, University Hospital, Aachen, Rennes University Hospital, Charite University, Berlin, Germany

Conditions

Hepatocellular InjuryLiver TransplantLiver Transplant Disorder

Unknown Phase

Hypothermic Oxygenated Perfusion (HOPE) of Human Liver Grafts

CompletedNCT01317342

University of ZurichHepatocellular Injury

Start: 2015-04-30End: 2020-08-30Updated: 2021-03-25

HOPE for Human Extended Criteria and Donation After Brain Death Donor (ECD-DBD) Liver Allografts

CompletedNCT03124641

University Hospital, AachenHepatocellular Injury, Liver Transplant

Start: 2017-01-17End: 2020-09-30Updated: 2021-01-28

Interest of Oxygenated Hypothermic Perfusion (PHO) in Preservation of Hepatic Grafts From Expanded Criteria Donors

CompletedNCT03376074

Rennes University HospitalHepatocellular Injury

Start: 2018-02-19End: 2019-02-07Updated: 2019-03-11

Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation

Charite University, Berlin, GermanyHepatocellular Injury, Liver Transplant Disorder

Start: 2021-01-14End: 2024-12-31Target: 213Updated: 2022-07-22

Related Papers

Effects of hypothermic oxygenated machine perfusion on bile composition after liver transplantation - Findings from a randomized controlled trial.

2025-10-17

End-ischemic hypothermic oxygenated perfusion for extended criteria donors in liver transplantation: a multicenter, randomized controlled trial—HOPExt

Trials2023-06-068 citations

Hypothermic Oxygenated Perfusion Improves Extended Criteria Donor Liver Graft Function and Reduces Duration of Hospitalization Without Extra Cost: The PERPHO Study

Liver Transplantation2020-11-2557 citations

Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial.

2019-03-1228 citations

Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD)

BMJ Open2017-10-0181 citations

Opportunities for scientific expansion of the deceased donor pool

Liver Transplantation2014-09-137 citations