Hyperpolarized 13C-Pyruvate

DRUG14 trials

Sponsors

Ivan de Kouchkovsky, MD, University of Texas Southwestern Medical Center, Sunnybrook Health Sciences Centre, University of Maryland, Baltimore, Robert Bok, MD, PhD

Conditions

Advanced Solid TumorBecker Muscular DystrophyBrain MetastasesBrain Tumor AdultCancer DiagnosisCardiac SarcoidosisCardiometabolic SyndromeCardiomyopathy, Hypertrophic

Early Phase 1

Pilot Study of (MR) Imaging with Pyruvate (13C) to Detect High Grade Prostate Cancer

RecruitingNCT02526368

Ivan de Kouchkovsky, MDLocalized Prostate Carcinoma, Prostate Cancer

Start: 2016-03-22End: 2026-12-31Target: 80Updated: 2025-02-26

Phase 1

Hyperpolarized 13C MR Imaging of Lactate in Patients With Locally Advanced Cervical Cancer (LACC) Cervical Cancer

TerminatedNCT03129776

Sunnybrook Health Sciences CentreUterine Cervical Neoplasms

Start: 2017-11-13End: 2022-09-15Updated: 2022-09-22

Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS)

RecruitingNCT03324360

Sunnybrook Health Sciences CentreBrain Metastases

Start: 2017-12-06End: 2027-01-01Target: 276Updated: 2026-01-29

Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas

RecruitingNCT04772456

University of Maryland, BaltimoreGlioma

Start: 2020-08-11End: 2027-12-31Target: 5Updated: 2025-09-22

Hyperpolarized 13C MRI as a Biomarker in Advanced Solid Tumors

RecruitingNCT05599048

Robert Bok, MD, PhDAdvanced Solid Tumor

Start: 2022-12-15End: 2026-01-31Target: 65Updated: 2025-03-24

HP Pyruvate MRI in Cancers

RecruitingNCT05697406

University of Maryland, BaltimoreImage, Tumors, Warburg Effect

Start: 2024-06-24End: 2028-12-01Target: 25Updated: 2025-09-22

Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury

RecruitingNCT06103201

University of Maryland, BaltimoreSubarachnoid Hemorrhage, Traumatic Brain Injury

Start: 2023-10-26End: 2027-11-26Target: 15Updated: 2025-05-11

Phase 2

Utility of Hyperpolarized 13C-pyruvate Metabolic Magnetic Resonance Imaging

RecruitingNCT04698564

University of Maryland, BaltimoreProstate Cancer

Start: 2020-12-01End: 2027-12-31Target: 20Updated: 2025-07-23

Lenvatinib Plus Pembrolizumab in Well Differentiated G3 Neuroendocrine Tumors

RecruitingNCT05746208

University of California, San FranciscoHigh Grade Neuroendocrine Carcinoma, Any Site, Neuroendocrine Tumors, Well-Differentiated Neuroendocrine Carcinoma

Start: 2023-07-17End: 2028-03-31Target: 29Updated: 2026-03-17

Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body

RecruitingNCT06645691

National Heart Centre SingaporeCancer Diagnosis, Cardiometabolic Syndrome, Cardiovascular Diseases +2

Start: 2024-10-17End: 2028-05-31Target: 200Updated: 2024-12-06

Unknown Phase

UTSW HP [13-C] Pyruvate Injection in HCM

CompletedNCT03057002

University of Texas Southwestern Medical CenterBecker Muscular Dystrophy, Cardiac Sarcoidosis, Cardiomyopathy, Hypertrophic +4

Start: 2018-05-01End: 2023-05-17Updated: 2025-03-26

Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)

RecruitingNCT03067467

University of Texas Southwestern Medical CenterBrain Tumor Adult

Start: 2019-06-01End: 2026-12-31Target: 25Updated: 2026-03-10

Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)

CompletedNCT04968210

University of Texas Southwestern Medical CenterPulmonary Arterial Hypertension

Start: 2022-05-27End: 2024-12-17Updated: 2025-01-13

Hyperpolarized 13C MRI to Predict Response in Pancreatic Cancer

RecruitingNCT06600906

University of California, San FranciscoLocally Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma, Pancreatic Ductal Adenocarcinoma

Start: 2024-10-01End: 2032-09-01Target: 70Updated: 2025-11-12