Hyperpolarized 129 Xenon

DRUG5 trials

Sponsors

Children's Hospital Medical Center, Cincinnati, University of Kansas Medical Center

Conditions

COPDCystic Fibrosis (CF)Gas Exchange ImpairmentHSCTLung Transplant RecipientNon-CF BronchiectasisRespiratoryRespiratory Disorders

Phase 1

Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

RecruitingNCT02272049

Children's Hospital Medical Center, CincinnatiRespiratory Disorders

Start: 2014-12-01End: 2029-08-31Target: 300Updated: 2026-02-17

Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

RecruitingNCT02316379

Children's Hospital Medical Center, CincinnatiRespiratory Disorders

Start: 2015-02-01End: 2032-12-24Target: 100Updated: 2026-09-14

Assessing Pulmonary Changes in HSCT

RecruitingNCT07823036

Children's Hospital Medical Center, CincinnatiGas Exchange Impairment, HSCT, Respiratory

Start: 2024-07-24End: 2029-07-01Target: 550Updated: 2026-09-16

Technical Development of Xe MRI

Enrolling by invitationNCT07823010

Children's Hospital Medical Center, CincinnatiHSCT, Lung Transplant Recipient

Start: 2024-01-01End: 2030-01-01Target: 550Updated: 2026-09-16

Unknown Phase

Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease

RecruitingNCT06985225

University of Kansas Medical CenterCOPD, Cystic Fibrosis (CF), Non-CF Bronchiectasis +1

Start: 2025-06-01End: 2026-12-01Target: 8Updated: 2026-07-01