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Hyperpolarized [1-13C]pyruvate

DRUG9 trials

Sponsors

Aarhus University, Aarhus Universitet, Region Midtjylland, Rigshospitalet

Conditions

ALS (Amyotrophic Lateral Sclerosis)Autosomal Dominant Polycystic kidney disease (ADPKD)Breast cancerDiabetic Kidney DiseaseHeart failureOvarian cancerPancreatic CancerPrimary liver cancer

Phase 1

Clinical and pathophysiological aspects of visualization of metabolic flux in the failing human heart using hyperpolarized [1-13C]-pyruvate cardiac magnetic resonance
RecruitingCTIS2024-515414-40-00
Region MidtjyllandHeart failure
Start: 2019-12-01Target: 30Updated: 2025-04-28

Phase 2

IMPROCAS - Improved Prediction of Ovarian Cancer Surgery
RecruitingCTIS2023-503398-39-00
Aarhus UniversityOvarian cancer
Start: 2024-03-01Target: 40Updated: 2025-05-30
QUANTITATIVE RENAL HYPERPOLARIZED [1-13C]PYRUVATE PERFUSION AND METABOLIC IMAGING IN DIABETIC KIDNEY DISEASE
RecruitingCTIS2023-508824-36-00
Aarhus UniversitetDiabetic Kidney Disease
Start: 2024-09-24Target: 27Updated: 2025-02-12
Chronic kidney disease – imaging the metabolic derangements with ultra-sensitive MRI
RecruitingCTIS2024-512491-35-00
Aarhus UniversitetAutosomal Dominant Polycystic kidney disease (ADPKD), cronic kidney disease
Start: 2024-04-01Target: 30Updated: 2024-12-20
MRI with hyperpolarized pyruvate in gliblastoma - a phase II study
RecruitingCTIS2024-515408-37-00
Aarhus Universitetcancer, glioblastoma multiforme
Start: 2020-04-01Target: 10Updated: 2025-11-28
Early detection of hepatocellular carcinoma by Hyperpolarized [1- 13C]pyruvate MRI
RecruitingCTIS2024-512490-27-00
Aarhus UniversitetPrimary liver cancer
Start: 2023-06-19Target: 46Updated: 2024-07-25
Phase IIa Clinical Trial: Feasibility Study on Non-Invasive Simultaneous Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Spectroscopy and 18F-FDG PET (hyperPET) for Metabolic Imaging in Patients with Cancer
RecruitingCTIS2024-516131-28-00
RigshospitaletBreast cancer, lymphomas, neuroendocrine neoplasms +1
Start: 2022-04-18Target: 15Updated: 2024-08-28
MRI of Neurometabolic Impairment in ALS and TIA Using Hyperpolarized Pyruvate
RecruitingCTIS2024-516954-24-00
Aarhus UniversitetALS (Amyotrophic Lateral Sclerosis), TIA (Transient Ischemic Attack)
Start: 2020-05-01Target: 46Updated: 2025-01-17
MR-HYPERPOLARISATION SCANNING WITH HYPERPOLARISED PYRUVATE (13C) IN PANCREATIC CANCER PATIENTS – A FEASIBILITY STUDY
RecruitingCTIS2024-517358-86-00
Aarhus UniversitetPancreatic Cancer
Start: 2024-09-13Target: 16Updated: 2025-09-25