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Hydroxocobalamin

DRUG6 trials

Sponsors

Rijnstate Hospital, Dartmouth-Hitchcock Medical Center, Mayo Clinic, Medical College of Wisconsin, Brigham and Women's Hospital

Conditions

Cardiac Valve DiseaseCoronary Artery DiseaseHydroxocobalamin Adverse ReactionHypotensionLiver Transplant; ComplicationsSeptic ShockVasoplegiaVasoplegic Syndrome

Phase 1

A Study on Hydroxocobalamin Given to Healthy Individual to Monitor Symptoms
CompletedNCT07469189
Brigham and Women's HospitalHydroxocobalamin Adverse Reaction
Start: 2023-01-02End: 2023-06-30Updated: 2026-03-13

Phase 2

Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
WithdrawnNCT03446599
Dartmouth-Hitchcock Medical CenterCardiac Valve Disease, Coronary Artery Disease, Hypotension +1
Start: 2019-11-30End: 2020-06-30Updated: 2020-03-02
Vitamin B12a Vasoplegic Syndrome
TerminatedNCT03735316
Mayo ClinicVasoplegic Syndrome
Start: 2019-04-25End: 2022-04-01Updated: 2023-05-10
A Trial of Vitamin B12 in Septic Shock
CompletedNCT03783091
Medical College of WisconsinSeptic Shock
Start: 2019-08-05End: 2023-02-23Updated: 2026-05-27

Phase 4

Vitamin Deficiencies and Suppletion in Morbid Obesity
CompletedNCT02270749
Rijnstate HospitalVitamin B12 Deficiency
Start: 2014-10-31End: 2016-06-30Updated: 2020-06-11
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
CompletedNCT04054999
Mayo ClinicLiver Transplant; Complications, Vasoplegic Syndrome
Start: 2019-11-30End: 2024-02-27Updated: 2024-06-24

Related Papers

High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial).
2022-09-2626 citations
Efficacy of oral compared with intramuscular vitamin B-12 supplementation after Roux-en-Y gastric bypass: a randomized controlled trial.
2018-07-0115 citations