HU6
Sponsors
Rivus Pharmaceuticals, Inc.
Conditions
Diabete Type 2Fatty LiverHeart Failure With Preserved Ejection FractionMASH - Metabolic Dysfunction-Associated SteatohepatitisNASH - Nonalcoholic SteatohepatitisNon-Alcoholic Fatty Liver DiseaseNonalcoholic SteatohepatitisObesity
Phase 1
Ascending Dose Study of HU6 in Healthy Volunteers
CompletedNCT04463017
Start: 2020-08-12End: 2021-04-01Updated: 2021-05-04
Multiple Ascending Dose Study of HU6 in High BMI Volunteers
CompletedNCT04709913
Start: 2021-01-04End: 2021-07-30Updated: 2021-08-16
Phase 1, Open-Label, Randomized, Study of the Safety and Pharmacokinetics of HU6
CompletedNCT07170189
Start: 2025-10-13End: 2025-12-04Updated: 2026-01-21
Phase 2
Phase 2a Study of HU6 in Subjects With Elevated Liver Fat and High BMI Volunteers
CompletedNCT04874233
Start: 2021-04-19End: 2021-12-15Updated: 2024-03-01
Exploratory Ph 2A, Double-Blind, Placebo-Controlled Dose Escalation Study of Safety, Tolerability, PD, & PK of HU6 for Subjects With Obese HFpEF
CompletedNCT05284617
Start: 2022-10-30End: 2024-05-30Updated: 2024-08-26
Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis
Active, not recruitingNCT05979779
Start: 2023-09-05End: 2025-06-30Updated: 2025-04-18
Ph 2a Study of HU6 on Energy Metabolism, Muscle and Liver Substrate Metabolism, and Mitochondrial Function in Subjects Who Are Overweight or Obese With Type 2 Diabetes
WithdrawnNCT06104358
Start: 2023-11-17End: 2025-03-31Updated: 2024-01-09
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
RecruitingNCT07491458
Start: 2026-02-13End: 2028-02-01Target: 180Updated: 2026-05-18