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HT-6184

DRUG4 trials

Sponsors

Halia Therapeutics, Inc.

Conditions

Anemia in Myelodysplastic SyndromesDiabetes Mellitus, Type 2Myelodysplastic SyndromeNormal Healthy SubjectsObesityPain

Phase 1

Study to Evaluate HT-6184 in Healthy Subjects
CompletedNCT05447546
Halia Therapeutics, Inc.Normal Healthy Subjects
Start: 2022-06-15End: 2023-07-20Updated: 2023-08-28

Phase 2

Evaluating Ability of HT-6184 to Reduce Inflammation and Pain After Third Molar Extraction
CompletedNCT06241742
Halia Therapeutics, Inc.Pain
Start: 2024-02-12End: 2024-04-30Updated: 2025-03-30
A Phase 2a Study of HT-6184 in Subjects With IPSS-R Very Low, Low or Intermediate Risk MDS and Anemia
Active, not recruitingNCT07052006
Halia Therapeutics, Inc.Anemia in Myelodysplastic Syndromes, Myelodysplastic Syndrome
Start: 2023-12-09End: 2026-10-15Updated: 2026-09-17
A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DM
WithdrawnNCT07172867
Halia Therapeutics, Inc.Diabetes Mellitus, Type 2, Obesity
Start: 2026-01-06End: 2026-01-23Updated: 2026-02-25

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The novel allosteric NEK7 inhibitor ofirnoflast (HT-6184) demonstrates robust and sustained hematologic response in subjects with IPSS-R very low, low or intermediate risk myelodysplastic syndrome (MDS) and symptomatic anemia
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The novel allosteric NEK7 inhibit ofirnoflast (HT-6184) reduces oxidized mitochondrial DNA in patients with low-risk myelodysplastic syndrome
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The novel allosteric NEK7 inhibitor ofirnoflast (HT-6184) suppresses IL-8 and other pro-inflammatory cytokines in patients with low-risk myelodysplastic syndrome and symptomatic anemia
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