Skip to content
FindTrial
Search trials
Search trials by condition, treatment, sponsor...
Sign In
HSV-Tk
GENETIC
3 trials
Sponsors
AGC Biologics S.p.A.
, The Methodist Hospital Research Institute
Conditions
Acute Leukemia (Category)
Hematological Malignancies
High-risk Prostate Cancer
Prostate Cancer
Phase 1
Infusion of Donor Lymphocytes Transduced With the Suicide Gene HSV TK in Patients With Haematological Malignancies
Completed
NCT00423124
AGC Biologics S.p.A.
Hematological Malignancies
Start: 2002-07-31
End: 2013-11-30
Updated: 2014-05-30
Phase 2
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
NCT03541928
The Methodist Hospital Research Institute
High-risk Prostate Cancer, Prostate Cancer
Start: 2018-08-02
End: 2023-07-31
Target: 60
Updated: 2021-04-06
Phase 3
Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia
Terminated
NCT00914628
AGC Biologics S.p.A.
Acute Leukemia (Category)
Start: 2010-04-12
End: 2019-11-30
Updated: 2021-06-22
Related Papers
Characterization and Functional Analysis of CD44v6.CAR T Cells Endowed with a New Low-Affinity Nerve Growth Factor Receptor-Based Spacer
Human Gene Therapy
2021-02-06
21 citations
Safety and Efficacy of Donor T Cells Engineered with Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK Cells) Given after T-Cell Depleted (TCD) Haploidentical Hematopoietic Transplantation (Haplo-HSCT): Results of a 14-Year Follow-Up in 45 Patients
Biology of Blood and Marrow Transplantation
2017-02-22
2 citations
Impact of Immune Reconstitution (IR) and Graft-Versus-Host Disease (GvHD) on Clinical Outcomes after Treatment with Donor T Cells Transduced to Express the Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK cells) in Acute Leukemia Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)
Blood
2016-12-02
4 citations
Haploidentical HSCT: a 15-year experience at San Raffaele.
2015-06-01
6 citations
Infusion of Donor Lymphocytes Genetically Engineered to Express the Herpes Simplex Virus Thymidine Kinase (HSV-TK) Suicide Gene after Haploidentical Hematopoietic Stem Cell Transplantation (HSCT): Preliminary Efficacy Data from the Randomized TK008 Study
Blood
2014-12-06
6 citations
Efficacy of HSV-TK<sup>+</sup> suicide gene donor lymphocytes after haploidentical transplantation (haplo-HSCT): Preliminary results of randomized TK008 study.
Journal of Clinical Oncology
2014-05-20
1 citations
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.
2009-04-01
371 citations