HSK21542

DRUG8 trials

Conditions

Chronic PainHealthy VolunteersHemodialysis Patients with Moderate-to-Severe PruritusNausea and Vomiting, Chemotherapy-InducedNausea and Vomiting, PostoperativePostoperative AnalgesiaPostoperative PainPostoperative Pain Management

Phase 1

Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers

CompletedNCT04110886

Sichuan Haisco Pharmaceutical Group Co., LtdChronic Pain, Postoperative Pain

Start: 2020-07-02End: 2021-01-05Updated: 2021-02-09

Safety, Tolerability and Pharmacokinetics of HSK21542 in Healthy Volunteers

CompletedNCT04213196

Sichuan Haisco Pharmaceutical Group Co., LtdHealthy Volunteers

Start: 2020-01-09End: 2020-12-07Updated: 2023-02-22

Phase 2

A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetics of HSK21542 Injection in Liver Disease Subjects With Pruritus

CompletedNCT04999787

Haisco Pharmaceutical Group Co., Ltd.Pruritus

Start: 2021-09-16End: 2022-08-03Updated: 2022-11-02

Evaluating the Efficacy and Safety of HSK21542 Injection in Chemotherapy-induced Nausea and Vomiting

Not yet recruitingNCT06593782

First Affiliated Hospital of Wenzhou Medical UniversityNausea and Vomiting, Chemotherapy-Induced

Start: 2024-09-16End: 2025-09-01Target: 180Updated: 2024-09-19

Phase 3

A Clinical Study to Evaluate Efficacy and Safety of HSK21542 for Postoperative Analgesia of Subjects Undergoing Elective Laparoscopic Surgery Under General Anesthesia

CompletedNCT04738357

Haisco Pharmaceutical Group Co., Ltd.Postoperative Analgesia

Start: 2021-03-24End: 2021-09-30Updated: 2023-02-21

A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients with Chronic Kidney Disease-Associated Pruritus

CompletedNCT05135390

Haisco Pharmaceutical Group Co., Ltd.Hemodialysis Patients with Moderate-to-Severe Pruritus, Pruritus

Start: 2022-06-17End: 2024-06-06Updated: 2024-12-31

A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery

CompletedNCT07186426

Haisco Pharmaceutical Group Co., Ltd.Postoperative Pain Management

Start: 2025-08-05End: 2026-02-24Updated: 2026-08-26

Phase 4

An Economic Study of HSK21542 Injection for Prevention of Postoperative Nausea and Vomiting

RecruitingNCT06359535

Mengchang YangNausea and Vomiting, Postoperative

Start: 2024-02-23End: 2024-11-06Target: 200Updated: 2024-04-11

BMJ2025-08-194 citations

HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials

Nature Communications2025-05-245 citations

Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study

Frontiers in Pharmacology2023-10-0910 citations