HRS-8427

DRUG5 trials

Conditions

Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)Gram-negative Bacterial InfectionsHealth VolunteerHealthy Cninese Adult MaleHospital-acquired Bacterial Pneumonia (HABP)Ventilator-associated Bacterial Pneumonia (VABP)

Phase 1

Pharmacokinetics Impact of HRS-8427 on Bupropion and Midazolam in Healthy Subjects

CompletedNCT07049107

Jiangsu HengRui Medicine Co., Ltd.Health Volunteer

Start: 2025-06-23End: 2025-07-21Updated: 2026-03-16

Study on the Mass Balance of [14C]HRS-8427 for Injection in Healthy Chinese Subjects

CompletedNCT07049562

Jiangsu HengRui Medicine Co., Ltd.Healthy Cninese Adult Male

Start: 2025-05-21End: 2025-06-18Updated: 2025-07-03

Pharmacokinetics and Safety of HRS-8427 in Healthy Volunteers and in Patients With Impaired Renal Function

CompletedNCT07070375

Jiangsu HengRui Medicine Co., Ltd.Gram-negative Bacterial Infections

Start: 2023-04-19End: 2023-08-23Updated: 2025-07-17

Phase 2

A Trial of HRS-8427 in the Treatment of Adults With Bacterial Pneumonia

RecruitingNCT06841731

Jiangsu HengRui Medicine Co., Ltd.Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)

Start: 2025-04-03End: 2026-02-28Target: 100Updated: 2025-04-22

Phase 3

A Trial of HRS-8427 in the Treatment of Adults With Complicated Urinary Tract Infection, Including Acute Pyelonephritis

RecruitingNCT06569056

Jiangsu HengRui Medicine Co., Ltd.Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)

Start: 2024-09-25End: 2025-11-30Target: 578Updated: 2025-01-22

Related Papers

Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects.