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High-dose methotrexate

DRUG5 trials

Sponsors

Federal Research Institute of Pediatric Hematology, Oncology and Immunology, St. Jude Children's Research Hospital, Protherics Medicines Development Limited, Wake Forest University Health Sciences, Rong Tao

Conditions

Acute Kidney InjuryAcute Lymphoblastic LeukemiaChildhood Acute Lymphoblastic LeukemiaDrug ToxicityExtranodal NK/T-cell LymphomaLeukemia, B-CellLeukemia, T-CellLymphoma, Non-Hodgkin's

Phase 2

Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma
TerminatedNCT02518750
St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia, Leukemia, B-Cell, Leukemia, T-Cell +1
Start: 2016-11-23End: 2018-03-11Updated: 2019-04-03
The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma
Not yet recruitingNCT07560826
Wake Forest University Health SciencesOsteosarcoma in Adolescents and Young Adults, Osteosarcoma in Children
Start: 2026-08-01End: 2028-12-01Target: 46Updated: 2026-06-25

Phase 3

BRIDGE-NK: Immunotherapy Versus Chemotherapy Induction Followed by Autologous HSCT in Advanced NKTCL
Not yet recruitingNCT07678229
Rong TaoExtranodal NK/T-cell Lymphoma
Start: 2026-07-01End: 2031-12-31Target: 150Updated: 2026-07-01

Unknown Phase

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2008
NCT01953770
Federal Research Institute of Pediatric Hematology, Oncology and ImmunologyChildhood Acute Lymphoblastic Leukemia
Start: 2008-02-29End: 2020-07-31Target: 3000Updated: 2020-02-05
Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate
NCT05899751
Protherics Medicines Development LimitedAcute Kidney Injury, Drug Toxicity
Start: 2022-04-01End: 2024-12-31Target: 1000Updated: 2024-05-10