Herceptin 600 mg solution for injection in vial
Sponsors
Institut Curie, F. Hoffmann-La Roche AG, Karolinska University Hospital, Solti Group, Roche Farma S.A.
Conditions
Breast cancerEarly human epidermal growth factor receptor 2 (HER2) positive breast cancerEarly or Locally Advanced/ Inflammatory HER2-Positive Breast CancerHER2- positive breast cancerHER2-POSITIVE EARLY BREAST CANCERHER2-positive locally advanced or metastatic breast cancerMetastatic HER2+ Breast cancerPatients with PIK3CA-mutant
Phase 1
Phase 2
"TUC-TOC": Tucatinib in combination with Oral Etoposide (VP16) - Trastuzumab in Patients with metastatic HER2+ Breast cancer after progression under Tucatinib-Capecitabine-Trastuzumab or toxicity related to capecitabine: a multicenter Phase II
RecruitingCTIS2022-500743-20-00
Start: 2023-12-19Target: 66Updated: 2025-02-27
PREDIX HER2 - Neoadjuvant response-guided treatment of HER2 positive
breast cancer. Part of a platform of translational phase II trials based on
molecular subtypes
Active, not recruitingCTIS2023-508411-23-00
Start: 2014-11-12Target: 200Updated: 2025-11-17
Chemotherapy-free trastuzumab and pertuzumab in HER2-positive breast cancer: FDG-PET response-adapted strategy
The PHERGain study.
Active, not recruitingCTIS2023-509923-42-00
Start: 2017-07-06Target: 345Updated: 2025-11-25
Image-guided de-escalation of neoadjuvant chemotherapy in HER2-positive breast cancer: the TRAIN-3 study
Active, not recruitingCTIS2024-516205-23-00
Start: 2019-04-09Target: 472Updated: 2024-11-12
Phase 3
TIME AND MOTION STUDY OF A SUBCUTANEOUS FIXED DOSE COMBINATION OF PERTUZUMAB AND TRASTUZUMAB FOR THE TREATMENT OF PATIENTS WITH HER2-POSITIVE EARLY BREAST CANCER (PHATIMA)
CompletedCTIS2023-509321-50-00
Start: 2021-04-15End: 2025-03-31Target: 34Updated: 2025-02-14
A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF ADJUVANT ATEZOLIZUMAB OR PLACEBO AND TRASTUZUMAB EMTANSINE FOR HER2-POSITIVE BREAST CANCER AT HIGH RISK OF RECURRENCE FOLLOWING PREOPERATIVE THERAPY
Active, not recruitingCTIS2023-503568-18-00
Start: 2021-04-13Target: 377Updated: 2025-08-27
A Phase IIIB, Multinational, Multicenter, Randomized, Open-Label Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administrationin Participants with Early or Locally Advanced/ Inflammatory HER2-Positive Breast Cancer
CompletedCTIS2023-506380-33-00
Start: 2022-06-28End: 2025-07-03Target: 32Updated: 2025-12-15