Healthy volunteer with proven G6PD deficiency

2 trials

Conditions

Malaria Primaquine radical cure glucose 6 phosphate dehydrogenase deficiencyMalaria glucose 6 phosphate dehydrogenase deficiency glucose 6 phosphate dehydrogenase deficiency Primaquine Malaria

Phase 1

Assessing the tolerability of a single dose of 45 mg of primaquine as an extension to assessing a potentially safer radical curative regimen of primaquine in healthy volunteers with glucose-6-phosphate dehydrogenase deficiency in Thailand

Active, not recruitingTCTR20220317004

University of OxfordMalaria glucose 6 phosphate dehydrogenase deficiency glucose 6 phosphate dehydrogenase deficiency Primaquine Malaria

Start: 2022-06-02Target: 28Updated: 2026-08-03

Phase 2

Assessing the tolerability of a potentially safer radical curative regimen of primaquine in healthy volunteers with glucose 6 phosphate dehydrogenase deficiency in Thailand

Active, not recruitingTCTR20170830002

University of OxfordMalaria Primaquine radical cure glucose 6 phosphate dehydrogenase deficiency

Start: 2018-11-21Target: 30Updated: 2026-08-03

Related Papers

Within-host modeling of primaquine-induced hemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers

Antimicrobial Agents and Chemotherapy2025-02-24

Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

eLife2024-02-061 citations