Haploidentical Hematopoietic Cell Transplantation

PROCEDURE7 trials

Sponsors

Medical College of Wisconsin, Johns Hopkins All Children's Hospital, Children's Oncology Group, City of Hope Medical Center, The First Affiliated Hospital of Soochow University

Conditions

Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 PositiveAcute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAplastic AnaemiaBone Marrow Failure SyndromeChronic Lymphocytic LeukemiaChronic Phase Chronic Myeloid Leukemia, BCR-ABL1 PositiveHematological Malignancy

Phase 1

A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia

RecruitingNCT05757310

City of Hope Medical CenterRecurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia

Start: 2024-11-15End: 2027-06-18Target: 6Updated: 2026-01-05

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

RecruitingNCT07020533

City of Hope Medical CenterAccelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia +9

Start: 2026-05-08End: 2030-02-14Target: 46Updated: 2026-03-27

Phase 2

Propylene Glycol-Free Melphalan HCl (EVOMELA®) in Combination With Fludarabine and Total Body Irradiation Based Reduced Intensity Conditioning for Haploidentical Transplantation

CompletedNCT03159702

Medical College of WisconsinHematological Malignancy, Multiple Myeloma

Start: 2017-12-08End: 2025-12-08Updated: 2026-01-27

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

RecruitingNCT04356469

Johns Hopkins All Children's HospitalBone Marrow Failure Syndrome, Hemoglobinopathy (Disorder), Severe Aplastic Anemia

Start: 2020-07-22End: 2026-06-30Target: 17Updated: 2025-06-24

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children

RecruitingNCT04414046

Johns Hopkins All Children's HospitalMetabolic Disease, Primary Immune Deficiency Disorders

Start: 2020-07-22End: 2026-06-30Target: 17Updated: 2025-06-24

Phase 3

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Active, not recruitingNCT05457556

Children's Oncology GroupAcute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia +1

Start: 2023-03-15End: 2026-06-30Target: 435Updated: 2025-12-22

Unknown Phase

A Multicenter, Randomized, Open-Label Study of Haplo-Cord HSCT for the Treatment of Aplastic Anemia

RecruitingNCT07499284

The First Affiliated Hospital of Soochow UniversityAplastic Anaemia

Start: 2025-10-01End: 2028-09-30Target: 224Updated: 2026-03-30