GSK2140944

DRUG4 trials

Sponsors

GlaxoSmithKline

Conditions

GonorrheaInfections, Respiratory Tract

Phase 1

This Study Will Investigate the Safety, Tolerability and Pharmacokinetic Profile of Repeat Oral Doses of GSK2140944 in Healthy Adult Subjects

CompletedNCT01706315

GlaxoSmithKlineInfections, Respiratory Tract

Start: 2012-10-17End: 2013-12-13Updated: 2017-05-09

A Single Oral Escalating Dose Study of GSK2140944 in Healthy Volunteers

CompletedNCT02202187

GlaxoSmithKlineInfections, Respiratory Tract

Start: 2011-09-26End: 2012-02-15Updated: 2017-06-12

Placebo and Moxifloxacin Controlled Cardiac Conduction Study of GSK2140944 in Healthy Volunteers

CompletedNCT02257398

GlaxoSmithKlineInfections, Respiratory Tract

Start: 2014-10-06End: 2015-03-02Updated: 2017-07-13

Phase 2

A Dose-Ranging Study Evaluating the Efficacy, Safety, and Tolerability of GSK2140944 in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria Gonorrhoeae

CompletedNCT02294682

GlaxoSmithKlineGonorrhea

Start: 2015-04-15End: 2016-07-27Updated: 2017-05-23

Related Papers

Pharmacokinetics, safety, and tolerability of gepotidacin administered as single or repeat ascending doses, in healthy adults and elderly subjects

Clinical and Translational Science2022-06-306 citations

Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections.

2022-01-0334 citations

Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae.

2018-11-2674 citations

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation

Clinical Infectious Diseases2018-03-22158 citations

O05.3 A phase ii, randomised, study in adult subjects evaluating the efficacy, safety, and tolerability of single doses of gepotidacin (GSK2140944) for treatment of uncomplicated urogenital gonorrhoea

2017-07-012 citations

A Phase I, Randomized, Double-Blinded, Placebo- and Moxifloxacin-Controlled, Four-Period Crossover Study To Evaluate the Effect of Gepotidacin on Cardiac Conduction as Assessed by 12-Lead Electrocardiogram in Healthy Volunteers

Antimicrobial Agents and Chemotherapy2017-02-2238 citations