Granulocytes

BIOLOGICAL2 trials

Sponsors

Shanghai East Hospital, University of Manchester

Conditions

Advanced CancerPediatric Cancer

Phase 1

Clinical Study of Granulocyte Infusion for Advanced Cancer

Shanghai East HospitalAdvanced Cancer

Start: 2019-12-01End: 2022-09-30Target: 100Updated: 2019-12-19

Unknown Phase

Granulocyte Transfusions After Umbilical Cord Blood Transplant

Active, not recruitingNCT05425043

University of ManchesterPediatric Cancer

Start: 2021-09-14End: 2026-06-30Target: 40Updated: 2026-06-09

Related Papers

Reproducible Transient, Significant, Early Donor-Derived T-Cell Expansion, Induced By Pooled Granulocyte Transfusion, during Mismatch T-Cell Replete Cord Blood Transplant - an Optimal Platform for Allogeneic Graft Versus Leukaemia: Results of a Prospective Phase I/II Clinical Trial

Blood2024-11-05

Abstract 24: Granulocytes to Induce Donor-Derived T Cell Expansion after T Replete, Mismatched CB in Post-Transplant Relapsed and Refractory Paediatric Acute Leukaemia: Results of Grans Trial

Stem Cells Translational Medicine2024-08-21

Granulocyte transfusion during cord blood transplant for relapsed, refractory <scp>AML</scp> is associated with massive <scp>CD8</scp><sup>+</sup> T‐cell expansion, significant cytokine release syndrome and induction of disease remission

British Journal of Haematology2023-05-217 citations

Donor-Derived, <i>I</i> <i>n Vivo</i> T-Cell Expansion Using Granulocyte Transfusions after Cord Blood Transplant Induces Remission in Children with Relapsed, Refractory Acute Myeloid Leukemia and Is Associated with a Cytokine Release Syndrome

Blood2022-11-15