Golcadomide
Sponsors
AbbVie Deutschland GmbH & Co. KG, Fondazione Italiana Linfomi Ets, Lymphoma Academic Research Organisation, Celgene Corp., LYSARC
Conditions
B-Cell Non-Hodgkin Lymphoma-RecurrentB-Cell Non-Hodgkin Lymphoma-RefractoryB-cell Non-Hodgkin's lymphomaDiffuse Large B-Cell Lymphoma-RecurrentDiffuse Large B-Cell Lymphoma-RefractoryDiffuse Large B-cell Lymphoma RefractoryDiffuse Large B-cells non-Hodgkin LymphomaDiffuse large B-cell lymphoma
Phase 1
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
RecruitingNCT05169515
Start: 2022-10-26End: 2029-09-15Target: 121Updated: 2026-03-19
CC-99282 + Rituximab Early Post CART for Non-Hodgkin's Lymphoma
RecruitingNCT06209619
Start: 2024-01-29End: 2026-12-31Target: 18Updated: 2026-02-27
Phase 1b/2, Open-Label Study to Evaluate Safety and Tolerability of Epcoritamab in Combination with Anti-Neoplastic Agents in Subjects with Non-Hodgkin Lymphoma
RecruitingCTIS2023-505347-38-00
Start: 2022-06-13Target: 59Updated: 2025-11-21
A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants
CompletedNCT06363630
Start: 2024-04-23End: 2024-08-29Updated: 2024-09-27
A PHASE I/II, MULTI-CENTER, OPEN-LABEL STUDY TO ASSESS THE SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF AN ORALLY AVAILABLE SMALL MOLECULE, CC-99282, ALONE AND IN COMBINATION WITH ANTI-LYMPHOMA AGENTS IN SUBJECTS WITH RELAPSED OR REFRACTORY NON-HODGKIN LYMPHOMAS (R/R NHL)
RecruitingCTIS2024-515690-10-00
Start: 2019-05-10Target: 204Updated: 2025-11-12
Golcadomide and Nivolumab in Patients With Non-Hodgkin Lymphoma With Refractory Disease After Chimeric Antigen T-cell Therapy
Not yet recruitingNCT06767956
Start: 2025-06-30End: 2028-04-30Target: 30Updated: 2025-06-04
PLATFORM - A PLATFORM TRIAL, EVALUATING NEW DRUGS OR COMBINATION IN RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMAS
RecruitingCTIS2024-514954-63-00
Start: 2025-08-20Target: 80Updated: 2025-12-03
A Platform Trial Evaluating New Drugs or Combination in R/R Peripheral T-cell Lymphomas
RecruitingNCT07018752
Start: 2025-08-20End: 2030-01-01Target: 49Updated: 2026-02-11
Phase 2
Treatment Of Newly-diagnosed Follicular Lymphoma With CELMoD Golcadomide, Rituximab +/- Nivolumab.
Active, not recruitingNCT05788081
Start: 2023-08-31End: 2027-06-01Target: 40Updated: 2025-08-20
Golcadomide Post-CAR T-cell in R/R Aggressive Large B-cell Lymphoma Patients With High Risk of Relapse
RecruitingNCT06271057
Start: 2024-06-14End: 2027-10-20Target: 65Updated: 2024-10-15
CARMOD - Golcadomide (BMS-986369) post-CAR T-cell in R/R Aggressive large B-cell lymphoma patients with high risk of relapse
RecruitingCTIS2023-506705-20-00
Start: 2024-06-14Target: 61Updated: 2024-05-28
A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma
Active, not recruitingNCT06425302
Start: 2024-08-30End: 2028-11-27Target: 90Updated: 2026-01-08
A Phase 2 Randomized, Open Label Study to Evaluate the Efficacy and Safety of Golcadomide in Combination with Rituximab in Patients with Newly Diagnosed Advanced Stage Follicular Lymphoma
Active, not recruitingCTIS2024-511304-16-00
Start: 2024-10-10Target: 37Updated: 2025-10-08
A combination of Rituximab and CC-99282 as front-line therapy for older frail patients with Diffuse Large B-cells non-Hodgkin Lymphoma evaluated with a simplified Geriatric Assessment (sGA): a phase II study of the Fondazione Italiana Linfomi (FIL).
RecruitingCTIS2023-506206-38-00
Start: 2025-04-09Target: 47Updated: 2025-12-23
Golcadomide and Rituximab as Bridging Therapy for Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma Before CAR T-cell Therapy
RecruitingNCT06834373
Start: 2025-04-02End: 2027-03-03Target: 41Updated: 2026-01-28
HOVON 176: Golcadomide (CC-99282) for relapsed and refractory primary large B-cell lymphoma of the central nervous system and secondary central nervous system lymphoma: a phase 2 study
RecruitingCTIS2024-517051-12-00
Start: 2025-09-16Target: 74Updated: 2025-06-02
Phase 3
Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
Active, not recruitingNCT06356129
Start: 2024-06-19End: 2029-11-20Target: 850Updated: 2026-02-12
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of Golcadomide Plus R-CHOP Chemotherapy vs Placebo Plus R-CHOP Chemotherapy in Participants with Previously Untreated High-risk Large B-cell Lymphoma
(GOLSEEK-1)
Active, not recruitingCTIS2023-510178-15-00
Start: 2024-07-31Target: 322Updated: 2025-09-10
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
RecruitingNCT06911502
Start: 2025-07-28End: 2030-07-31Target: 400Updated: 2025-12-05
A Phase 3, Multicenter, Randomized, Open Label Study to Compare the Efficacy and Safety of Golcadomide in Combination with Rituximab (Golca + R) Vs Investigator’s Choice in Participants with Relapsed/Refractory Follicular Lymphoma (GOLSEEK-4)
RecruitingCTIS2024-519152-82-00
Start: 2025-09-03Target: 130Updated: 2025-09-08