Glyburide for Injection

DRUG3 trials

Sponsors

Biogen, Remedy Pharmaceuticals, Inc.

Conditions

Ischemic StrokeMalignant EdemaStrokeTraumatic Brain Injury

Phase 1

Safety Study of RP-1127 (Glyburide for Injection) in Healthy Volunteers

CompletedNCT01132703

BiogenStroke, Traumatic Brain Injury

Start: 2010-01-07End: 2010-05-07Updated: 2021-06-21

Glyburide Advantage in Malignant Edema and Stroke Pilot

CompletedNCT01268683

Remedy Pharmaceuticals, Inc.Ischemic Stroke

Start: 2011-05-26End: 2012-06-07Updated: 2024-11-22

Phase 2

Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals

CompletedNCT01794182

Remedy Pharmaceuticals, Inc.Ischemic Stroke, Malignant Edema

Start: 2013-06-13End: 2016-04-04Updated: 2024-11-12

Related Papers

Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans.

2019-11-296 citations

Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction

Stroke2019-09-2078 citations

Glibenclamide in aneurysmatic subarachnoid hemorrhage (GASH): study protocol for a randomized controlled trial.

2019-07-0914 citations

Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial.

2018-11-1659 citations

Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction

Stroke2018-05-2270 citations

Abstract 15: Long Term Outcomes of Intravenous Glyburide in Patients 70 Years of Age or Under: Subgroup Analysis From the Phase II GAMES-RP Study of Patients with Large Hemispheric Infarction

Stroke2017-02-01

Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial.

2016-08-23185 citations

GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP Trial: Intermediate Endpoint Analysis as Proof-Of-Concept (S7.006)

Neurology2016-04-05

GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP Trial: Intermediate Endpoint Analysis as Proof-Of-Concept (I11.010)

Neurology2016-04-05

Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke

Stroke2013-11-06106 citations