GLPG1972

DRUG3 trials

Sponsors

Galapagos NV

Conditions

HealthyOsteoarthritisOsteoarthritis.

Phase 1

Study to Compare Bioavailability of GLPG1972 Given as 2 Different Tablet Formulations Versus an Oral Solution

CompletedNCT03143725

Galapagos NVHealthy

Start: 2017-04-14End: 2017-06-06Updated: 2017-06-20

Phase 2

A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Participants With Knee Osteoarthritis

CompletedNCT03595618

Galapagos NVOsteoarthritis

Start: 2018-08-14End: 2020-07-14Updated: 2021-07-28

Unknown Phase

A Phase I, open-label, drug-drug interaction study between multiple oral doses of GLPG1972 and a single dose of midazolam in healthy male subjects.

Active, not recruitingNL-OMON44611

Galapagos NVOsteoarthritis.

Start: 2017-07-17Target: 18Updated: 2024-02-28

Related Papers

Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial.

2023-04-1325 citations

Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip

Clinical Pharmacology in Drug Development2021-12-0222 citations

The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis.

2021-08-1614 citations

Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis

Journal of Medicinal Chemistry2021-03-1551 citations