GLPG0634
Sponsors
Alfasigma S.p.A., Galapagos NV
Conditions
Crohn's DiseaseHealthyJuvenile idiopathic arthritisRenal ImpairmentRheumatoid ArthritisUlcerative colitisjuvenile idiopathic arthritis
Phase 1
First-in-Human Single Ascending and Multiple Dose of GLPG0634
CompletedNCT01179581
Start: 2010-08-31End: 2011-03-31Updated: 2011-03-24
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Oral Doses of GLPG0634 in Healthy Subjects
CompletedNCT01419990
Start: 2011-08-31End: 2011-10-31Updated: 2012-08-15
A Phase I, Open Interaction Study Between GLPG0634 and Midazolam in Healthy Subjects
CompletedNCT01798979
Start: 2013-02-28End: 2013-04-30Updated: 2013-05-07
Study to Evaluate GLPG0634 in Subjects With Renal Impairment Compared to Healthy Subjects
CompletedNCT02084199
Start: 2014-03-31End: 2014-07-31Updated: 2014-07-22
An open-label, multiple dose, multicenter study to evaluate the pharmacokinetics, safety, and tolerability of filgotinib in children and adolescents from 8 to less than 18 years of age with juvenile idiopathic arthritis
RecruitingCTIS2023-505844-21-00
Start: 2024-02-14Target: 50Updated: 2025-09-03
Phase 2
Safety and Preliminary Efficacy of GLPG0634 in Methotrexate-refractory Active Rheumatoid Arthritis Patients
CompletedNCT01384422
Start: 2011-06-30End: 2011-11-30Updated: 2012-08-15
Dose-ranging Study With GLPG0634 in Methotrexate-refractory Active Rheumatoid Arthritis Patients
CompletedNCT01668641
Start: 2012-05-31End: 2012-10-31Updated: 2013-06-27
Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)
CompletedNCT01888874
Start: 2013-07-17End: 2015-05-14Updated: 2020-11-17
Dose-finding Study of GLPG0634 as Monotherapy in Active Rheumatoid Arthritis (RA) Participants (DARWIN2)
CompletedNCT01894516
Start: 2013-10-08End: 2015-05-29Updated: 2020-12-16
Efficacy and Safety of GLPG0634 in Subjects With Active Crohn's Disease
CompletedNCT02048618
Start: 2014-02-28End: 2016-02-29Updated: 2016-02-23
Phase 3
A multicenter study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of filgotinib, with single arm induction and maintenance, in pediatric subjects (8 to <18 years of age) with moderately to severely active ulcerative colitis
RecruitingCTIS2024-511458-32-00
Start: 2025-06-15Target: 68Updated: 2026-01-23
Open Label Extension (OLE), multiple dose study to evaluate pharmacokinetics, safety, tolerability and efficacy of filgotinib in children and adolescents from 8 years to less than 18 years of age with juvenile idiopathic arthritis (JIA).
Not yet recruitingCTIS2025-523239-21-00
Target: 18Updated: 2026-04-01
Related Papers
3 more papers not shown