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DRUG3 trials

Sponsors

Fondazione Gimema Franco Mandelli Onlus, Masarykova Univerzita

Conditions

Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.Chronic Myeloid Leukemia (CML) in Chronic Phase (CP)chronic myeloid leukemia

Phase 2

A Prospective Phase II Clinical Trial Evaluating the Efficacy and the Safety of Tyrosine Kinase Inhibitors Withdrawal After a Previous Two-step Dose Reduction in Patients With Chronic Myeloid Leukemia in Deep Molecular Remission

Active, not recruitingCTIS2024-514592-17-00

Masarykova Univerzitachronic myeloid leukemia

Start: 2020-06-16Target: 221Updated: 2025-11-06

Phase 3

Newly Diagnosed Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL). Sequential Treatment with Ponatinib and the Bispecific Monoclonal Antibody Blinatumomab vs Chemotherapy and Imatinib. ALL2820

Active, not recruitingCTIS2023-508968-30-00

Fondazione Gimema Franco Mandelli OnlusAdult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

Start: 2021-09-08Target: 236Updated: 2024-10-01

Phase 4

Sustained treatment-free remission in BCR-ABL+ chronic myeloid leukemia: a prospective study comparing Nilotinib versus Imatinib with switch to Nilotinib in absence of optimal response. SUSTRENIM Study – GIMEMA CML1415

Active, not recruitingCTIS2023-510434-83-00

Fondazione Gimema Franco Mandelli OnlusChronic Myeloid Leukemia (CML) in Chronic Phase (CP)

Start: 2016-10-17Target: 450Updated: 2025-04-11