Gleevec

DRUG16 trials

Sponsors

M.D. Anderson Cancer Center, Novartis Pharmaceuticals, University of Michigan Rogel Cancer Center, Gustave Roussy, Cancer Campus, Grand Paris, Steven E. Coutre

Conditions

Advanced MelanomaAll Indications for Glivec/Gleevec and TasignaCancerChronic Myelogenous LeukemiaEosinophiliaHypereosinophilic SyndromeLeukemiaLeukemia, Myeloid

Phase 1

Study of Temzolomide and Gleevec in Advanced Melanoma

TerminatedNCT00667953

Abramson Cancer Center at Penn MedicineAdvanced Melanoma, Melanoma

Start: 2003-01-31End: 2011-03-09Updated: 2023-03-30

Pilot Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patient With Plexiform Neurofibromas

CompletedNCT01140360

Kent RobertsonNeurofibromas, Neurofibromatosis

Start: 2012-02-29End: 2016-12-31Updated: 2017-07-02

Phase 2

Therapy of Early Chronic Phase CML With Higher-Dose Gleevec, Alpha Interferon, and Low-Dose Ara-C

TerminatedNCT00038649

M.D. Anderson Cancer CenterMyelogenous Leukemia, Chronic, Chronic Phase

Start: 2001-06-30End: 2013-11-30Updated: 2018-10-09

Therapy of Early Chronic Phase CML With Gleevec

CompletedNCT00048672

M.D. Anderson Cancer CenterLeukemia, Myeloid, Chronic-Phase

Start: 2001-03-31End: 2013-08-31Updated: 2016-01-20

Gleevec Maintenance Therapy After Induction Irinotecan and Cisplatin in Patients With C-Kit Positive Extensive SCLC

CompletedNCT00156286

University of Michigan Rogel Cancer CenterSmall Cell Lung Cancer

Start: 2002-03-31End: 2006-04-30Target: 20Updated: 2010-11-16

Glivec Phase II Pediatric Study

TerminatedNCT00180830

Gustave Roussy, Cancer Campus, Grand ParisCancer

Start: 2003-12-31Target: 36Updated: 2006-09-11

Phase II Gleevec Idiopathic Hypereosinophilic Syndrome

TerminatedNCT00230334

Steven E. CoutreEosinophilia, Hypereosinophilic Syndrome

Start: 2003-06-12End: 2007-05-31Updated: 2021-05-10

A Study of Imatinib and Docetaxel in Prostate Cancer

CompletedNCT00251225

Leonard ApplemanProstate Cancer

Start: 2005-08-31End: 2014-03-31Updated: 2017-08-09

Gleevec/Low-Dose Ara-C Study for Elderly Patients With AML and Myelodysplastic Syndromes

CompletedNCT00451997

M.D. Anderson Cancer CenterLeukemia, Myeloid, Myelodysplastic Syndromes

Start: 2004-03-31End: 2007-04-30Updated: 2012-08-01

Safety Study of Gleevec® in Children With Pulmonary Hypertension

TerminatedNCT00583115

Indiana UniversityPulmonary Hypertension

Start: 2007-10-31End: 2013-12-31Updated: 2015-10-29

Late Chronic Phase Chronic Myelogenous Leukemia

CompletedNCT01092741

M.D. Anderson Cancer CenterLeukemia

Start: 2001-07-31End: 2013-09-30Updated: 2016-05-11

Treatment of Polycythemia Vera With Gleevec

CompletedNCT01120821

Weill Medical College of Cornell UniversityPolycythemia Vera

Start: 2002-08-31End: 2007-06-30Updated: 2010-05-17

Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas

CompletedNCT01673009

Indiana UniversityNeurofibromatosis

Start: 2006-05-31End: 2012-08-31Updated: 2016-04-06

Phase 3

High-Dose Gleevec Alone or in Combination With Peg-Intron and GM-CSF in Early Phase Chronic Myelogenous Leukemia (CML)

CompletedNCT00050531

M.D. Anderson Cancer CenterLeukemia, Myeloid, Chronic

Start: 2003-04-30End: 2015-08-31Updated: 2016-05-11

Phase 4

Gleevec Trial in Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia

CompletedNCT00081926

Novartis PharmaceuticalsChronic Myelogenous Leukemia

Start: 2003-10-31End: 2007-03-31Target: 112Updated: 2009-11-23

Unknown Phase

A Global Imatinib and Nilotinib Pregnancy Exposure Registry

CompletedNCT01289054

Novartis PharmaceuticalsAll Indications for Glivec/Gleevec and Tasigna

Start: 2011-01-31End: 2015-03-31Updated: 2015-04-15

Related Papers

Analysis of cardiovascular and arteriothrombotic adverse events in chronic-phase CML patients after frontline TKIs

Blood Advances2019-03-18121 citations

Clonal chromosomal abnormalities appearing in Philadelphia chromosome–negative metaphases during CML treatment

Blood2017-08-2371 citations

Clinical Application of Artificial Intelligence in Patients with Chronic Myeloid Leukemia in Chronic Phase

Blood2016-12-025 citations

Prediction for Sustained Deep Molecular Response of BCR-ABL Levels in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP)

Blood2016-12-02

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.

2012-10-23153 citations