GI-4000
Sponsors
GlobeImmune, Georgetown University, ImmunityBio, Inc.
Conditions
Colon CancerColorectal CancerColorectal Cancer MetastaticHead and Neck Squamous Cell CarcinomaHepatocellular Carcinoma Non-resectableHepatocellular Carcinoma RecurrentMetastatic Pancreatic CancerNSCLC
Phase 1
QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy
TerminatedNCT03136406
Start: 2017-08-11End: 2019-11-01Updated: 2024-06-11
QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors
WithdrawnNCT03169738
Start: 2018-02-28End: 2021-12-28Updated: 2025-02-21
QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC
WithdrawnNCT03169777
Start: 2018-08-31End: 2021-12-28Updated: 2025-02-21
QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy
WithdrawnNCT03169764
Start: 2017-12-31End: 2021-12-28Updated: 2025-02-24
QUILT-3.049: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Combination Immunotherapy in Subjects With TNBC Who Have Progressed on or After Anthracycline-based Chemotherapy
WithdrawnNCT03175666
Start: 2017-12-31End: 2021-12-28Updated: 2025-02-21
QUILT-3.048: NANT Urothelial Cancer Vaccine: Combination Immunotherapy in Subjects With Urothelial Cancer Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy
WithdrawnNCT03197571
Start: 2017-12-31End: 2021-12-28Updated: 2025-02-21
QUILT-3.051: NANT Ovarian Cancer Vaccine: Combination Immunotherapy in Subjects With Epithelial Ovarian Cancer Who Have Progressed on or After Standard-of-care (SoC) Therapy
WithdrawnNCT03197584
Start: 2017-12-31End: 2021-12-28Updated: 2025-02-21
QUILT-3.060: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy
TerminatedNCT03329248
Start: 2017-11-06End: 2019-11-01Updated: 2024-12-12
QUILT-3.067: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With TNBC Who Have Progressed on or After Standard-of-care Therapy.
TerminatedNCT03387085
Start: 2018-03-19End: 2024-01-16Updated: 2024-08-09
QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed
TerminatedNCT03387111
Start: 2018-01-09End: 2021-01-11Updated: 2024-08-05
QUILT-3.070:Pancreatic Cancer Vaccine: Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy
TerminatedNCT03387098
Start: 2017-12-28End: 2019-01-15Updated: 2024-05-22
QUILT-3.072: NANT Hepatocellular Carcinoma (HCC) Vaccine
WithdrawnNCT03563170
Start: 2018-05-25End: 2019-08-23Updated: 2021-03-18
QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine
TerminatedNCT03563157
Start: 2018-09-28End: 2019-08-21Updated: 2024-12-11
QUILT-3.080: NANT Pancreatic Cancer Vaccine
TerminatedNCT03586869
Start: 2018-07-17End: 2019-08-01Updated: 2024-08-27
Phase 2
Safety and Efficacy of the Therapeutic Vaccine GI-4000 in Combination With Gemcitabine Versus Placebo for the Treatment of Non-metastatic, Post-resection Pancreas Cancer
CompletedNCT00300950
Start: 2006-01-31End: 2015-02-28Updated: 2015-04-06
A Pilot Phase 2 Trial of the Immunogenicity, and Safety of GI-4000; an Inactivated Recombinant S. Cerevisiae Expressing Mutant Ras Protein, as Consolidation Therapy Following Curative Treatment for Stage I-III Non-Small Cell Lung Cancer (NSCLC) With Tumor Sequence Confirmation of K-ras Mutation
CompletedNCT00655161
Start: 2008-04-30End: 2013-11-30Updated: 2014-01-29
A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI
TerminatedNCT01322815
Start: 2010-10-31End: 2015-12-31Updated: 2016-08-15
QUILT-3.057: NANT Neoadjuvant Triple- Negative Breast Cancer (TNBC) Vaccine
WithdrawnNCT03554109
Start: 2018-09-30End: 2022-02-09Updated: 2025-02-21
QUILT-3.088: NANT Pancreatic Cancer Vaccine
WithdrawnNCT03563144
Start: 2018-08-31End: 2022-02-09Updated: 2025-02-21
QUILT-2.024: Phase 2 Neoadjuvant, Consolidation, and Adjuvant Combination NANT Immunotherapy Versus Standard of Care in Subjects With Resectable Non-small Cell Lung Cancer
WithdrawnNCT03574649
Start: 2018-06-30End: 2018-08-22Updated: 2025-02-21