Genome sequencing

GENETIC8 trials

Sponsors

British Columbia Cancer Agency, M.D. Anderson Cancer Center, VA Boston Healthcare System, Centre Hospitalier Universitaire Dijon, Brigham and Women's Hospital

Conditions

Advanced CancersCancers That Cannot be Treated With Curative IntentCritical IllnessDevelopmental AnomaliesGenetic DiseaseGenetic Predisposition to DiseaseHereditary DiseasesHyperparathyroidism

Unknown Phase

Personalized Oncogenomics (POG) Program of British Columbia

RecruitingNCT02155621

British Columbia Cancer AgencyMetastatic Cancers, Advanced Cancers, Cancers That Cannot be Treated With Curative Intent

Start: 2014-07-31End: 2026-03-31Target: 5000Updated: 2025-09-22

Variables That Are Correlated to Developing Multiple Endocrine Neoplasia (MEN) and Pancreatic Neuroendocrine Tumors (PNET)

M.D. Anderson Cancer CenterMultiple Endocrine Neoplasia, Pancreatic Neuroendocrine Tumors, Hyperparathyroidism

Start: 2012-10-09End: 2023-10-31Target: 53Updated: 2019-09-12

The VetSeq Study: a Pilot Study of Genome Sequencing in Veteran Care

CompletedNCT03380819

VA Boston Healthcare SystemRare Diseases, Genetic Disease

Start: 2017-12-29End: 2022-12-31Updated: 2023-04-26

Study of the Diagnostic Value of Rapid High Throughput Genome Sequencing Analysis in Diagnostic Emergency Situations

CompletedNCT03956069

Centre Hospitalier Universitaire DijonDevelopmental Anomalies

Start: 2020-06-23End: 2022-07-25Updated: 2022-09-21

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

CompletedNCT05161169

Brigham and Women's HospitalGenetic Predisposition to Disease, Hereditary Diseases

Start: 2022-12-21End: 2025-06-30Updated: 2026-03-05

Mechanisms of Type 1 Diabetes Endophenotypes

RecruitingNCT05764850

Pediatric Clinical Research PlatformType 1 Diabetes Mellitus, Genetic Predisposition to Disease

Start: 2023-02-01End: 2026-02-01Target: 150Updated: 2023-03-13

The HIEnome Study: Genome Sequencing for Perinatal HIE

RecruitingNCT06762795

Baylor College of MedicineHypoxic Ischemic Encephalopathy of Newborn, Hypoxic Ischemic Encephalopathy, Hypoxic Ischemic Encephalopathy (HIE)

Start: 2025-05-15End: 2027-06-30Target: 25Updated: 2025-10-01

UW ISeqU: Clinical Impact of Whole-genome Sequencing in Adults

Enrolling by invitationNCT07718971

University of WashingtonHereditary Diseases, Critical Illness

Start: 2026-07-01End: 2032-07-01Target: 1000Updated: 2026-07-22

Related Papers

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration.

2023-03-2420 citations

Abstract B066: Elucidating the role of insulin receptor isoform expression in metastatic pancreatic ductal adenocarcinoma

Cancer Research2022-11-151 citations

Abstract LB129: Analysis of KRAS wildtype pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma

Cancer Research2022-06-15

Molecular characterization of long-term and short-term survivors of advanced pancreatic ductal adenocarcinoma.

Journal of Clinical Oncology2022-06-014 citations

Abstract 630: Response to nivolumab in a pediatric chordoma with overexpression of brachyury

Cancer Research2021-07-011 citations

Beyond <i>BRCA</i>? clinical utility of homologous recombination deficiency in gastrointestinal cancers.

Journal of Clinical Oncology2021-01-20

Tumor infiltrating neutrophils and gland formation predict overall survival and molecular subgroups in pancreatic ductal adenocarcinoma

Cancer Medicine2020-12-2813 citations

Whole genome and transcriptome analysis and the link between insulin receptor aberration and diabetes in PDAC.

Journal of Clinical Oncology2020-02-01

Patient selection for a developmental therapeutics program using whole genome and Transcriptome analysis.

2020-01-061 citations

Afatinib as a novel potential treatment option for <i>NRG1</i> fusion-positive tumors.

Journal of Global Oncology2019-10-076 citations

Comprehensive transcriptome analysis reveals link between epigenetic dysregulation, endogenous retrovirus expression and immunogenicity in metastatic colorectal carcinoma.

Journal of Clinical Oncology2019-05-204 citations

Comprehensive genomic analysis of metastatic pancreatic ductal adenocarcinoma (mPDAC) reveals a significant proportion of clinical actionable aberrations.

Journal of Clinical Oncology2019-05-201 citations

Whole genome and transcriptome analysis (WGTA) of metastatic adrenocortical carcinoma (mACC).

Journal of Clinical Oncology2019-05-201 citations

Whole genome and transcriptome analysis (WGTA) of metastatic adrenocortical carcinoma (mACC).

Journal of Clinical Oncology2019-03-013 citations

Comprehensive genomic analysis of metastatic pancreatic ductal adenocarcinoma (mPDAC) reveals a significant proportion of clinical actionable aberrations.

Journal of Clinical Oncology2019-01-291 citations

Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer.

2017-12-0179 citations

Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing

Molecular Case Studies2017-11-0143 citations

Management of germline findings revealed throughout the course of tumor-normal whole genome sequencing in oncology.

Journal of Clinical Oncology2017-05-20

Abstract B81: Gene expression analysis demonstrates prognostic subtypes in metastatic pancreatic ductal adenocarcinoma (PDAC)

Cancer Research2016-12-141 citations

Comprehensive genomic analysis in metastatic pancreatic ductal adenocarcinoma (PDAC).

Journal of Clinical Oncology2016-02-011 citations