GDC-0941
Sponsors
Genentech, Inc.
Conditions
Breast CancerHealthy VolunteerHealthy VolunteersMetastatic Breast CancerNon-Hodgkin's Lymphoma, Solid CancersNon-Squamous Non-Small Cell Lung CancerNon-Squamous Non-Small Cell Lung Cancer, Solid CancersSolid Cancers
Phase 1
A Study of GDC-0941 in Patients With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma for Which Standard Therapy Either Does Not Exist or Has Proven Ineffective or Intolerable
CompletedNCT00876122
Start: 2008-03-31End: 2012-07-31Updated: 2016-11-02
A Study of GDC-0941 in Participants With Locally Advanced or Metastatic Solid Tumors for Which Standard Therapy Either Does Not Exist or Has Proven Ineffective or Intolerable
CompletedNCT00876109
Start: 2007-10-31End: 2013-11-30Updated: 2016-11-02
Trastuzumab and Trastuzumab-MCC-DM1 Administered Intravenously and GDC-0941 Administered Orally to Patients With HER2-Positive Metastatic Breast Cancer Who Have Progressed on Previous Trastuzumab-Based Therapy
CompletedNCT00928330
Start: 2009-07-31End: 2014-01-31Updated: 2016-11-02
A Study of the Safety and Pharmacology Of PI3-Kinase Inhibitor GDC-0941 In Combination With Either Paclitaxel And Carboplatin (With or Without Bevacizumab) or Pemetrexed, Cisplatin, And Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer
CompletedNCT00974584
Start: 2009-10-31End: 2015-03-31Updated: 2016-11-02
A Study of the Safety and Pharmacology of GDC-0941 in Combination With Erlotinib in Patients With Advanced Solid Tumors
CompletedNCT00975182
Start: 2009-09-30End: 2014-09-30Updated: 2016-11-02
A Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0941 and the Effect of Food and Proton Pump Inhibition on GDC-0941 Tablet Pharmacokinetics in Healthy Volunteers
CompletedNCT00999128
Start: 2009-10-26End: 2010-02-26Updated: 2017-02-09
A Study to Determine the Relative Bioavailability of a Tablet Formulation of GDC-0941 and the Effect of Ketoconazole on the Pharmacokinetics of the GDC-0941 Tablet
CompletedNCT01240226
Start: 2010-11-30End: 2010-12-31Updated: 2017-03-03
Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-0941 Following Single Oral Dose Administration in Healthy Male Subjects
CompletedNCT01474668
Start: 2011-10-31End: 2011-10-31Updated: 2016-11-02
A Study of the Effect of Formulation and Tablet Hardness on the Bioavailability of Pictilisib in Healthy Volunteers
CompletedNCT02092831
Start: 2014-04-30End: 2014-05-31Updated: 2016-11-02
Phase 2
Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Participants Resistant to Aromatase Inhibitor Therapy
CompletedNCT01437566
Start: 2011-10-31End: 2016-04-30Updated: 2016-11-02
A Study of Paclitaxel With GDC-0941 Versus Paclitaxel With Placebo in Participants With Locally Recurrent or Metastatic Breast Cancer
CompletedNCT01740336
Start: 2013-02-06End: 2015-12-10Updated: 2017-04-24