GBT440
Sponsors
Global Blood Therapeutics, Pfizer, Global Blood Therapeutics, Inc.
Conditions
Anemia
sickel cell diseaseAnemia, Sickle CellCardio-pulmonary FunctionHealthy SubjectsHepatic ImpairmentHypoxemiaIdiopathic Pulmonary FibrosisRenal Impairment
Phase 1
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Disease
CompletedNCT02285088
Start: 2014-12-31End: 2017-05-31Updated: 2018-02-15
A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects
CompletedNCT02497924
Start: 2015-06-30End: 2016-07-31Updated: 2017-04-12
A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy Subjects
CompletedNCT02567695
Start: 2015-09-30End: 2016-06-30Updated: 2017-04-12
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy Subjects
CompletedNCT02567682
Start: 2015-09-30End: 2016-05-31Updated: 2017-04-12
Study to Evaluate Effects of Investigational Drug on Oxygenation in Healthy Volunteers Under Hypoxic Conditions
TerminatedNCT03051711
Start: 2016-12-31End: 2018-02-21Updated: 2019-10-04
Single-Dose PK and Safety Study of GBT440 in Subjects With Hepatic Impairment
CompletedNCT03114540
Start: 2017-03-17End: 2018-03-22Updated: 2023-07-18
Single-Dose PK Study of GBT440 in Subjects With Renal Impairment
CompletedNCT03161015
Start: 2016-11-30End: 2017-07-06Updated: 2018-02-22
Phase 2
Study to Evaluate the Safety and Tolerability of GBT440 Administered to Subjects With IPF
CompletedNCT02846324
Start: 2016-06-30End: 2017-11-30Updated: 2020-10-20
Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest
TerminatedNCT02989168
Start: 2016-11-30End: 2017-10-23Updated: 2020-08-21
An Extension Study to Further Evaluate the Safety, Tolerability of GBT440 in Patients With Sickle Cell Disease Who Participated in the Study GBT440-001
CompletedNCT03041909
Start: 2016-08-31End: 2017-08-31Updated: 2019-01-02