Gallium Ga 68 FAPi-46

DRUG6 trials

Sponsors

Jonsson Comprehensive Cancer Center, Mayo Clinic

Conditions

Anal CarcinomaBladder CarcinomaBreast CarcinomaCancer of Unknown Primary SiteCervical CarcinomaCholangiocarcinomaColon CarcinomaColorectal Carcinoma

Early Phase 1

Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues

Active, not recruitingNCT04147494

Jonsson Comprehensive Cancer CenterBreast Carcinoma, Colon Carcinoma, Esophageal Carcinoma +8

Start: 2019-11-05End: 2031-10-17Updated: 2025-08-12

68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma

Active, not recruitingNCT04457258

Jonsson Comprehensive Cancer CenterMetastatic Sarcoma, Recurrent Sarcoma, Sarcoma

Start: 2020-09-08End: 2027-07-21Updated: 2025-08-12

Phase 1

Prospective Exploratory Study of FAPi PET/CT in Prostate Cancer With Histopathology Validation

Active, not recruitingNCT04457232

Jonsson Comprehensive Cancer CenterMetastatic Malignant Neoplasm in the Prostate Gland, Prostate Carcinoma, Recurrent Prostate Carcinoma

Start: 2020-09-09End: 2026-05-30Updated: 2025-07-15

Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers

Active, not recruitingNCT04459273

Jonsson Comprehensive Cancer CenterBladder Carcinoma, Cancer of Unknown Primary Site, Cervical Carcinoma +13

Start: 2020-08-27End: 2027-07-01Updated: 2026-02-05

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

RecruitingNCT07118176

Jonsson Comprehensive Cancer CenterAnal Carcinoma, Bladder Carcinoma, Breast Carcinoma +31

Start: 2025-08-01End: 2027-09-07Target: 30Updated: 2025-08-12

Phase 2

Investigational Scan (68Ga-FAPI-46 PET/CT) for Imaging of Cancer-Associated Fibroblasts for Localized Pancreatic Ductal Adenocarcinoma

RecruitingNCT05518903

Mayo ClinicLocalized Pancreatic Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma, Stage 0 Pancreatic Cancer AJCC v8 +2

Start: 2022-11-15End: 2028-06-30Target: 130Updated: 2025-10-02

Related Papers

FAP Expression in Renal Tumors Assessed by [<sup>68</sup>Ga]Ga-FAPI-46 PET Imaging and FAP Immunohistochemistry: A Case Series of Six Patients from the Prospective Exploratory Trial NCT04147494.

2026-01-02

FAP and PSMA Expression by Immunohistochemistry and PET Imaging in Castration-Resistant Prostate Cancer: A Translational Pilot Study

Journal of Nuclear Medicine2024-10-307 citations

Incidental Focal<sup>68</sup>Ga-FAPI-46 Uptake in a Urachal Remnant: A Potential Pitfall Mimicking a Malignant Peritoneal Lesion

Journal of Nuclear Medicine2022-12-295 citations

Abstract LB038: Validation of FAPi PET biodistribution by immunohistochemistry in patients with solid cancers: a prospective exploratory study

Cancer Research2021-07-01

Validation of FAPi PET biodistribution by immunohistochemistry in patients with solid cancers: A prospective exploratory study.

Journal of Clinical Oncology2021-05-204 citations

Incidental Detection of Elastofibroma Dorsi With 68Ga-FAPI-46 and 18F-FDG PET/CT in a Patient With Esophageal Cancer

Clinical Nuclear Medicine2020-07-2217 citations