GA2

BIOLOGICAL2 trials

Sponsors

Leiden University Medical Center

Conditions

Malaria,FalciparumPlasmodium Falciparum Malaria

Early Phase 1

Coadministration of GA2 Sporozoites With Adjuvants

Leiden University Medical CenterMalaria,Falciparum

Start: 2023-02-03End: 2024-12-31Target: 45Updated: 2023-02-10

Phase 1

Safety and Preliminary Protective Efficacy of Genetically Attenuated GA2 Parasites.

CompletedNCT04577066

Leiden University Medical CenterPlasmodium Falciparum Malaria

Start: 2021-09-27End: 2022-12-22Updated: 2023-01-13

Related Papers

Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial

Nature Medicine2025-01-0120 citations

Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite

New England Journal of Medicine2024-11-2032 citations

Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial.

2023-04-074 citations