Frozen Plasma Product, Human

DRUG2 trials

Sponsors

University of Maryland, Baltimore, Octapharma

Conditions

Bleeding Cardiac Surgery PatientsHeart Disease End StageHeart Failure，Congestive

Phase 3

Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation

TerminatedNCT03341156

University of Maryland, BaltimoreHeart Disease End Stage, Heart Failure，Congestive

Start: 2018-07-11End: 2025-02-20Updated: 2025-05-23

Active-control Randomized Trial Comparing 4-factor Prothrombin Complex Concentrate With Frozen Plasma in Cardiac Surgery

CompletedNCT05523297

OctapharmaBleeding Cardiac Surgery Patients

Start: 2022-11-30End: 2024-06-27Updated: 2025-08-15

Related Papers

The association of estimated citrate load with frozen plasma versus four-factor prothrombin complex concentrate for coagulopathy after cardiac surgery: a post hoc exploratory analysis of the FARES-II randomised controlled trial

BJA Open2026-06-29

Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.

2025-05-0118 citations

Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

BMJ Open2024-08-017 citations

Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients-a randomized multicentre pilot study (PLTS-1).

2024-06-152 citations

Randomized, Active-Control Phase 3 Study of Four-Factor Prothrombin Complex Concentrate Versus Frozen Plasma in Bleeding Adult Cardiac Surgery Patients

Blood2023-11-02