Fractionated Stereotactic Radiation Therapy

RADIATION4 trials

Sponsors

City of Hope Medical Center, National Cancer Institute (NCI), NRG Oncology

Conditions

Allogeneic Hematopoietic Stem Cell Transplant RecipientAnatomic Stage IV Breast Cancer AJCC v8Diffuse Astrocytoma, IDH-WildtypeGrade 1 MeningiomaGrade 2 MeningiomaHematopoietic and Lymphoid Cell NeoplasmMetastatic Breast CarcinomaMetastatic Digestive System Carcinoma

Phase 1

Human Lysozyme Goat Milk for the Prevention of Graft Versus Host Disease in Patients With Blood Cancer Undergoing a Donor Stem Cell Transplant

Active, not recruitingNCT04177004

City of Hope Medical CenterAllogeneic Hematopoietic Stem Cell Transplant Recipient, Hematopoietic and Lymphoid Cell Neoplasm

Start: 2021-04-30End: 2026-10-27Updated: 2026-07-13

Phase 2

Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

Active, not recruitingNCT04729959

National Cancer Institute (NCI)Diffuse Astrocytoma, IDH-Wildtype, Recurrent Glioblastoma

Start: 2022-03-11End: 2026-09-04Updated: 2026-08-27

Phase 3

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

RecruitingNCT06500455

NRG OncologyAnatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma +7

Start: 2024-12-12End: 2033-06-30Target: 269Updated: 2026-08-17

Comparing Radiation After Surgery to Observation After Surgery in Patients With Clinical Low-Risk, Molecular High-Risk Meningioma, and Evaluating Observation After Surgery in Patients With Clinical and Molecular Low-Risk Meningioma

Not yet recruitingNCT07785687

NRG OncologyGrade 1 Meningioma, Grade 2 Meningioma, Recurrent Grade 1 Meningioma

Start: 2027-01-28End: 2040-06-30Target: 464Updated: 2026-08-25

Related Papers

GLIOMA-05 A NOVEL CONCEPT FOR TREATMENT OF GLIOBLASTOMA: VAGUS NERVE ELECTRICAL STIMULATION FOR SUPPRESSION OF CYTOKINE (IL-6) SIGNALING

Neuro-Oncology Advances2023-10-311 citations

CTIM-21. NRG-BN010: A SAFETY RUN-IN AND PHASE II STUDY EVALUATING THE COMBINATION OF TOCILIZUMAB, ATEZOLIZUMAB, AND FRACTIONATED STEREOTACTIC RADIOTHERAPY IN RECURRENT GLIOBLASTOMA – TRIAL IN PROGRESS

Neuro-Oncology2022-11-017 citations