FOR INTRAVASCULAR ADM.
Sponsors
Alexion Pharmaceuticals Inc., Assistance Publique Hopitaux De Paris, Janssen Cilag International, Toleranzia AB, Nuvig Therapeutics Inc.
Conditions
Adult patients with immune thrombocytopenia (ITP) with mild to severe bleeding manifestationsFetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)Fulminant myocarditisHYPOPHOSPHATASIAImmune Thrombocytopenia (ITP)Young Adults and adults with R/R B-cell acute lymphoblastic leukemia (BCP-ALL) or a B cell lymphoma (BCL)generalised myasthenia gravis
Phase 1
Phase 2
Pulse corticosteroids or/and Immunoglobulins to treat fulminant Myocarditis: a double-blind randomized controlled adaptive trial (The CORIUM study)
Not yet recruitingCTIS2023-506599-28-01
Target: 120Updated: 2025-01-09
An Open-label, Intra-participant Dose Escalation Study to Evaluate the Safety, Tolerability, and Efficacy of Intravenous NVG-2089 in Participants with Immune Thrombocytopenia
RecruitingCTIS2024-520359-26-00
Start: 2025-08-20Target: 25Updated: 2025-09-04
Phase 3
Intravenous Immunoglobulin plus oral prednisone or high-dose dexamethasone, for adults with immune thrombocytopenia (ITP) with moderate and severe bleeding: a randomized, multicentre trial (IVIORDEX)
RecruitingCTIS2024-516403-16-00
Start: 2022-04-07Target: 272Updated: 2025-05-27
Multicenter, Open-Label, Randomized Study of Nipocalimab or IVIG in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
RecruitingCTIS2023-509434-19-00
Start: 2025-02-10Target: 13Updated: 2026-01-21
PREV-CART - A multicentric phase III randomized clinical trial open-label, comparing immunoglobulin replacement therapy (IgRT) and antibiotic prophylaxis (AP) in patients treated by CD19-targeted Chimeric Antigen Receptor (CAR)T Cells for a B cell acute lymphoblastic leukemia or a B cell lymphoma
Not yet recruitingCTIS2025-521571-30-00
Target: 228Updated: 2026-04-13