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Following provision of informed consent, participants will be randomly allocated to one of two groups (1:1) using a computer generated dynamic procedure (minimisation) with a random component. Minimis

2 trials

Sponsors

Queen Mary University of London

Conditions

Major elective gastrointestinal surgery SurgeryPatients undergoing major surgery requiring general anaesthesia Surgery Patients undergoing major surgery requiring general anaesthesia

Phase 3

Stopping perioperative angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers in major noncardiac surgery
Active, not recruitingISRCTN17251494
Queen Mary University of LondonPatients undergoing major surgery requiring general anaesthesia Surgery Patients undergoing major surgery requiring general anaesthesia
Start: 2017-06-01Target: 260Updated: 2025-09-08

Unknown Phase

Optimisation of perioperative cardiovascular management to improve surgical outcome II
Active, not recruitingISRCTN39653756
Queen Mary University of LondonMajor elective gastrointestinal surgery Surgery
Start: 2016-12-31Target: 2502Updated: 2025-01-06

Related Papers

Preoperative activation of the renin-angiotensin system and myocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial.
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Cardiac output-guided haemodynamic therapy for patients undergoing major gastrointestinal surgery: OPTIMISE II randomised clinical trial
BMJ2024-12-0320 citations
Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery
BMJ Open2019-01-0158 citations
Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners.
2018-06-297 citations