FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)

DRUG11 trials

Conditions

ChemotherapyColorectal CancerEsophageal AdenocarcinomaGastric Cancer (Diagnosis)Gastroesophageal AdenocarcinomaGastroesophageal Junction AdenocarcinomaHepatic Arterial Infusion ChemotherapyIntrahepatic Cholangiocarcinoma (Icc)

Phase 1

A Phase I/II Study of Cediranib (AZD2171) in Japanese Metastatic Colorectal Cancer Patients in Combination With FOLFOX

CompletedNCT00494221

AstraZenecaMetastatic Colorectal Cancer

Start: 2007-06-30End: 2012-08-31Updated: 2014-03-27

A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors

RecruitingNCT06598007

Crossignal Therapeutics, Inc.Solid Tumor, Adult, Colorectal Cancer, Pancreatic Ductal Adenocarcinoma

Start: 2024-09-20End: 2027-06-30Target: 78Updated: 2026-05-29

Phase 2

Cryoablation Combined With Lenvatinib Plus Tislelizumab Compared With FOLFOX in Patients With Advanced Intrahepatic Cholangiocarcinoma (CASTLE-ZS-01)

RecruitingNCT06860477

Fudan UniversityIntrahepatic Cholangiocellular Carcinoma

Start: 2025-03-18End: 2028-03-15Target: 92Updated: 2025-04-06

FOLFOX-HAIC Combined With Donafenib and Pucotenlimab as First-Line Treatment for Unresectable Intrahepatic Cholangiocarcinoma

Not yet recruitingNCT07353827

Sun Yat-sen UniversityIntrahepatic Cholangiocarcinoma (Icc), Hepatic Arterial Infusion Chemotherapy

Start: 2026-02-01End: 2028-12-31Target: 36Updated: 2026-01-20

Randomized Study of Plasma ctDNA Methylation to Guide Adjuvant Chemotherapy Decisions in High-Risk T3N0 Colorectal Cancer

RecruitingNCT07562711

Fudan UniversityctDNA, Chemotherapy, Colorectal Cancer

Start: 2024-11-01End: 2027-12-31Target: 340Updated: 2026-05-01

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

Not yet recruitingNCT07603375

Duke UniversityEsophageal Adenocarcinoma

Start: 2026-09-01End: 2034-02-01Target: 60Updated: 2026-08-28

TAIC FOLFOX for Locally Advanced G/GEJA

RecruitingNCT07655024

Guang'anmen Hospital of China Academy of Chinese Medical SciencesGastric Cancer (Diagnosis), Gastroesophageal Junction Adenocarcinoma

Start: 2025-11-01End: 2028-12-01Target: 31Updated: 2026-06-17

Phase 3

Cediranib (AZD2171, RECENTIN™) in Addition to Chemotherapy in Patients With Untreated Metastatic Colorectal Cancer

CompletedNCT00399035

AstraZenecaMetastatic Colorectal Cancer

Start: 2006-11-30End: 2016-08-31Updated: 2016-12-28

Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer

RecruitingNCT06783491

Maimónides Biomedical Research Institute of CórdobaLocally Advanced Colorectal Cancer

Start: 2026-05-26End: 2030-12-31Target: 1083Updated: 2026-06-08

Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer

Not yet recruitingNCT07472868

J. W. A. BurgerLocally Advanced Rectal Carcinoma

Start: 2026-03-03End: 2034-03-02Target: 394Updated: 2026-03-16

Paclitaxel, Ramucirumab and Tislelizumab Switch Maintenance in Advanced HER2-negative and PD-L1 TAP Score of 5 or More Advanced Gastroesophageal Adenocarcinoma

Not yet recruitingNCT07763171

Gruppo Oncologico del Nord-OvestGastroesophageal Adenocarcinoma

Start: 2026-09-01End: 2031-09-01Target: 244Updated: 2026-08-18

Related Papers

A national, multicentre, randomised, controlled, parallel-arms, phase III clinical trial of neoadjuvant FOLFOXIRI and chemoradiotherapy versus neoadjuvant CAPOX/FOLFOX and chemoradiotherapy in patients with high-risk locally advanced rectal cancer: study protocol of the MEND-IT II trial

BMC Cancer2026-05-18

KRAS mutations are associated with inferior clinical outcome in patients with metastatic colorectal cancer, but are not predictive for benefit with cediranib.