Focused ultrasound with neuro-navigator-controlled sonication

DEVICE2 trials

Sponsors

Columbia University

Conditions

Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantDiffuse Pontine and Thalamic Gliomas

Phase 1

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

TerminatedNCT04804709

Columbia UniversityDiffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Diffuse Pontine and Thalamic Gliomas

Start: 2021-07-28End: 2022-03-31Updated: 2025-06-08

FUS Etoposide for DMG

RecruitingNCT05762419

Columbia UniversityDiffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant

Start: 2023-06-05End: 2027-12-01Target: 10Updated: 2026-01-28

Related Papers

DIPG-93. OVERALL EXPERIENCE OF TWO PHASE I CLINICAL TRIALS WITH FOCUSED ULTRASOUND-MEDIATED BLOOD BRAIN BARRIER OPENING IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS WITH PROGRESSIVE DIPG/DMG USING A NEURONAVIGATION-BASED DEVICE

Neuro-Oncology2024-06-18