Flucytosine

DRUG13 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Pfizer, InterMune, City of Hope Medical Center, ANRS, Emerging Infectious Diseases

Conditions

Adult Anaplastic AstrocytomaAdult Anaplastic OligoastrocytomaAdult Anaplastic OligodendrogliomaAdult Brain TumorAdult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaAdult Mixed Glioma

Phase 1

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

CompletedNCT01172964

City of Hope Medical CenterAdult Anaplastic Astrocytoma, Adult Anaplastic Oligoastrocytoma, Adult Anaplastic Oligodendroglioma +9

Start: 2010-08-31End: 2015-02-11Updated: 2017-11-09

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

CompletedNCT02015819

City of Hope Medical CenterAdult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma +4

Start: 2014-10-07End: 2017-10-07Updated: 2021-10-20

Phase 2

Dexamethasone in Cryptococcal Meningitis

CompletedNCT00000776

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections, Meningitis, Cryptococcal

End: 1996-09-30Target: 36Updated: 2021-10-28

Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis

CompletedNCT00012467

InterMuneHIV Infections, Meningitis, Cryptococcal

Start: 2000-01-31End: 2001-07-31Target: 60Updated: 2009-06-03

Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa

ANRS, Emerging Infectious DiseasesCryptococcal Meningitis, HIV

Start: 2012-05-31End: 2016-09-30Updated: 2016-07-12

Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis

CompletedNCT06414512

University of MinnesotaCryptococcal Meningitis

Start: 2024-04-09End: 2024-10-02Updated: 2025-08-27

Phase 3

AmB Dose for Cryptococcal Meningitis

Shanghai Public Health Clinical CenterCryptococcal Meningitis, HIV Infections

Start: 2020-01-02End: 2022-04-30Target: 40Updated: 2019-10-29

Unknown Phase

A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.

CompletedNCT00002113

PfizerHIV Infections, Meningitis, Cryptococcal

Target: 64Updated: 2005-06-24

A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis

CompletedNCT00000639

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections, Meningitis, Cryptococcal

End: 1997-09-30Target: 400Updated: 2021-11-02

Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

CompletedNCT00002075

PfizerHIV Infections, Meningitis, Cryptococcal

Updated: 2005-06-24

A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis

CompletedNCT00002305

PfizerHIV Infections, Meningitis, Cryptococcal

Updated: 2005-06-24

Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

CompletedNCT00000708

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections, Meningitis, Cryptococcal

Target: 120Updated: 2011-03-14

Clinical Study of ABCD in the Treatment of Cryptococcal Meningitis

Peking Union Medical College HospitalCryptococcal Meningitis

Start: 2022-08-22End: 2023-04-30Target: 30Updated: 2022-07-22

Related Papers

Evaluating the Use of Lower Dose Flucytosine for the Treatment of Cryptococcal Meningitis: A Clinical Trial

Clinical Infectious Diseases2025-08-07

Phase 1 study of multiple intracerebral doses of a neural stem cell-based oncolytic virotherapy for treatment of recurrent high-grade gliomas.

Journal of Clinical Oncology2024-06-016 citations

Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study

BMJ Open Diabetes Research & Care2019-03-0135 citations

Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival.

2018-03-144 citations

Getting More Skin in the Game: Using Human Neural Stem Cells Transdifferentiated From Fibroblasts to Target Malignant Gliomas

Neurosurgery2017-08-011 citations

Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma

Neurosurgery2013-07-193 citations