Fluarix Quadrivalent

BIOLOGICAL4 trials

Sponsors

GlaxoSmithKline, Emory University, ModernaTX, Inc.

Conditions

InfluenzaInfluenza, HumanSeasonal Influenza

Phase 1

A Study to Evaluate the Reactogenicity, Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Investigational Supra-seasonal Universal Influenza Vaccines - Inactivated (SUIVs) (GSK3816302A) in Healthy Adults Aged 18 to 39 Years

CompletedNCT03275389

GlaxoSmithKlineInfluenza, Human

Start: 2017-09-08End: 2020-03-26Updated: 2021-05-07

Phase 3

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Influenza Vaccine When Administered in Children Who Previously Participated in Study 115345

CompletedNCT01702454

GlaxoSmithKlineInfluenza

Start: 2012-10-06End: 2013-06-05Updated: 2018-09-07

A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older

CompletedNCT05566639

ModernaTX, Inc.Seasonal Influenza

Start: 2022-09-14End: 2024-01-05Updated: 2025-01-16

Phase 4

The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics

TerminatedNCT03686514

Emory UniversityInfluenza

Start: 2018-10-22End: 2020-06-20Updated: 2022-07-13

Related Papers

An mRNA-based seasonal influenza vaccine in adults: Results of two phase 3 randomized clinical trials and correlate of protection analysis of hemagglutination inhibition titers

Human Vaccines & Immunotherapeutics2025-04-0213 citations

Safety and Immunogenicity of mRNA-1010, an Investigational Seasonal Influenza Vaccine, in Healthy Adults: Final Results From a Phase 1/2 Randomized Trial

The Journal of Infectious Diseases2024-06-2737 citations

A chimeric haemagglutinin-based universal influenza virus vaccine boosts human cellular immune responses directed towards the conserved haemagglutinin stalk domain and the viral nucleoprotein.

2024-05-277 citations

Safety and immunogenicity of a phase 1/2 randomized clinical trial of a quadrivalent, mRNA-based seasonal influenza vaccine (mRNA-1010) in healthy adults: interim analysis.

2023-06-1984 citations

Reactogenicity, safety, and immunogenicity of chimeric haemagglutinin influenza split-virion vaccines, adjuvanted with AS01 or AS03 or non-adjuvanted: a phase 1-2 randomised controlled trial.

2022-04-2121 citations

The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination

Vaccines2020-11-0712 citations

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts.

2019-12-0624 citations

Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Naïve Children

The Pediatric Infectious Disease Journal2018-10-164 citations