FLUAD®

BIOLOGICAL3 trials

Sponsors

Chiltern Pesquisa Clinica Ltda, Duke University, ModernaTX, Inc.

Conditions

Adverse Drug EventChronic Heart DiseaseChronic Pulmonary DiseaseCytomegalovirusDiabetes MellitusH1N1 Influenza VirusInjection Site ReactionPain

Phase 1

A Study of Modified mRNA Vaccines in Healthy Adults

CompletedNCT05397223

ModernaTX, Inc.Cytomegalovirus, Respiratory Syncytial Virus, SARS-CoV-2 +1

Start: 2022-05-24End: 2026-02-27Updated: 2026-03-12

Phase 3

Immunogenicity, Safety, and Tolerability of an MF59-Adjuvanted Versus Non-Adjuvanted Influenza Vaccines in Patients With Chronic Pulmonary Disease, Chronic Heart Disease, or Diabetes Mellitus

CompletedNCT01032395

Chiltern Pesquisa Clinica LtdaChronic Heart Disease, Chronic Pulmonary Disease, Diabetes Mellitus +1

Start: 2010-03-31End: 2012-08-31Updated: 2013-06-14

Phase 4

FLUAD® vs. Fluzone® High-Dose Study

CompletedNCT03183908

Duke UniversityAdverse Drug Event, Injection Site Reaction, Pain +2

Start: 2017-08-28End: 2019-02-14Updated: 2021-03-30

Related Papers

An mRNA influenza vaccine induces immunity comparable to an adjuvanted vaccine in a randomized trial.

2026-01-14

P-1454. mRNA-Based Respiratory Syncytial Virus Vaccine mRNA-1345 Induces Robust, Polyfunctional, and Durable CD4+ and CD8+ T Cell Responses with Similar Features in Adults Across Age Groups

Open Forum Infectious Diseases2026-01-01

P-1453. Characterization of longitudinal humoral and cellular immunogenicity following 2 or 3 doses of an mRNA-based cytomegalovirus vaccine in healthy adults

Open Forum Infectious Diseases2026-01-01

P-1452. A Seasonal Influenza Hemagglutinin mRNA-Based Vaccine Induces Humoral and Cellular Immunity Comparable to an Adjuvanted Inactivated Influenza Virus Vaccine

Open Forum Infectious Diseases2026-01-01

mRNA-1010 influenza vaccine elicits distinct and enhanced humoral immunity compared to adjuvanted inactivated vaccines.

2025-12-15

An mRNA-based cytomegalovirus vaccine induces robust T-cell immune responses in cytomegalovirus-seropositive adults who have undergone allogeneic hematopoietic cell transplantation

Blood2025-11-03

Shared clinical and immunologic features of mRNA vaccines: preliminary results from a comparative clinical study

Frontiers in Immunology2025-04-105 citations

Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial.

2023-07-018 citations

Safety and immunogenicity of a phase 1/2 randomized clinical trial of a quadrivalent, mRNA-based seasonal influenza vaccine (mRNA-1010) in healthy adults: interim analysis.

2023-06-1984 citations

Safety, Reactogenicity, and Health-Related Quality of Life After Trivalent Adjuvanted vs Trivalent High-Dose Inactivated Influenza Vaccines in Older Adults

JAMA Network Open2021-01-1427 citations

How many unpublished studies? ClinicalTrials.gov (n = 2614 studies): diabetes | Closed Studies | Interventional Studies | Phase 3, 4 | Search Date: Oct 27, 2014

Figshare2014-01-01